Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.

abstract：:All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here ...

journal_title：Nature immunology

authors： Feng D,Bond CJ,Ely LK,Maynard J,Garcia KC

更新日期：2007-09-01 00:00:00

abstract：:PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastati...

journal_title：Nature immunology

authors： Okazaki T,Chikuma S,Iwai Y,Fagarasan S,Honjo T

更新日期：2013-12-01 00:00:00

abstract：:Autoreactive T cells are eliminated in the thymus to prevent autoimmunity by promiscuous expression of tissue-restricted self-antigens in medullary thymic epithelial cells. This expression is dependent on the transcription factor Fezf2, as well as the transcriptional regulator Aire, but the entire picture of the trans...

journal_title：Nature immunology

authors： Tomofuji Y,Takaba H,Suzuki HI,Benlaribi R,Martinez CDP,Abe Y,Morishita Y,Okamura T,Taguchi A,Kodama T,Takayanagi H

更新日期：2020-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key initiators of the innate immune response and promote adaptive immunity. Much has been learned about the role of TLRs in human immunity from studies linking TLR genetic variation with disease. First, monogenic disorders associated with complete deficiency in certain TLR pathways, such...

journal_title：Nature immunology

authors： Netea MG,Wijmenga C,O'Neill LA

更新日期：2012-05-18 00:00:00

abstract：:Induction of the transcriptional repressor Bcl-6 in CD4(+) T cells is critical for the differentiation of follicular helper T cells (T(FH) cells), which are essential for B cell-mediated immunity. In contrast, the transcription factor Blimp1 (encoded by Prdm1) inhibits T(FH) differentiation by antagonizing Bcl-6. Here...

journal_title：Nature immunology

authors： Xu L,Cao Y,Xie Z,Huang Q,Bai Q,Yang X,He R,Hao Y,Wang H,Zhao T,Fan Z,Qin A,Ye J,Zhou X,Ye L,Wu Y

更新日期：2015-09-01 00:00:00

abstract：:In the version of this Research Highlight initially published, the url for the linked article was incorrect ( https://doi.org/10.1172/JCI90647JCI90647 ). The correct link is https://doi.org/10.1172/JCI90647 . The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature immunology

authors： Fehervari Z

更新日期：2018-08-01 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4 (IL-4) early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we have defined three subsets of i...

journal_title：Nature immunology

authors： Lee YJ,Holzapfel KL,Zhu J,Jameson SC,Hogquist KA

更新日期：2013-11-01 00:00:00

abstract：:The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), tha...

journal_title：Nature immunology

authors： Smole U,Gour N,Phelan J,Hofer G,Köhler C,Kratzer B,Tauber PA,Xiao X,Yao N,Dvorak J,Caraballo L,Puerta L,Rosskopf S,Chakir J,Malle E,Lane AP,Pickl WF,Lajoie S,Wills-Karp M

更新日期：2020-07-01 00:00:00

abstract：:Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs. Loss of STAT5 ...

journal_title：Nature immunology

authors： Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SF

更新日期：2013-04-01 00:00:00

abstract：:CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release-activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combined immunodeficiency disease in humans. Here we generated CRACM1-deficient mice in which beta-galactosidase activity 'reporte...

journal_title：Nature immunology

authors： Vig M,DeHaven WI,Bird GS,Billingsley JM,Wang H,Rao PE,Hutchings AB,Jouvin MH,Putney JW,Kinet JP

更新日期：2008-01-01 00:00:00

abstract：:Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed ...

journal_title：Nature immunology

authors： Ginhoux F,Schultze JL,Murray PJ,Ochando J,Biswas SK

更新日期：2016-01-01 00:00:00

abstract：:Chemokines facilitate leukocyte migration and positioning as well as other processes such as angiogenesis and leukocyte degranulation. The burgeoning knowledge on chemokines and their receptors has influenced many aspects of immunology, in part because cell migration is intimately related to leukocyte function. This o...

journal_title：Nature immunology

authors： Mackay CR

更新日期：2001-02-01 00:00:00

abstract：:Cooperation between different innate signaling pathways induced by pattern-recognition receptors (PRRs) on dendritic cells (DCs) is crucial for tailoring adaptive immunity to pathogens. Here we show that carbohydrate-specific signaling through the C-type lectin DC-SIGN tailored cytokine production in response to disti...

journal_title：Nature immunology

authors： Gringhuis SI,den Dunnen J,Litjens M,van der Vlist M,Geijtenbeek TB

更新日期：2009-10-01 00:00:00

abstract：:The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxi...

journal_title：Nature immunology

authors： Yuk JM,Shin DM,Lee HM,Kim JJ,Kim SW,Jin HS,Yang CS,Park KA,Chanda D,Kim DK,Huang SM,Lee SK,Lee CH,Kim JM,Song CH,Lee SY,Hur GM,Moore DD,Choi HS,Jo EK

更新日期：2011-07-03 00:00:00

abstract：:Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR)...

journal_title：Nature immunology

authors： Quann EJ,Liu X,Altan-Bonnet G,Huse M

更新日期：2011-05-22 00:00:00

abstract：:The kappa intronic (MiE(kappa)) and 3' (3'E(kappa)) enhancers are both quantitatively important to, but not essential for, immunoglobulin kappa rearrangement. To determine the functional redundancy between these two enhancers, B cells derived from mutant embryonic stem cells--in which both MiE(kappa) and 3'E(kappa) we...

journal_title：Nature immunology

authors： Inlay M,Alt FW,Baltimore D,Xu Y

更新日期：2002-05-01 00:00:00

abstract：:Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal transducer and activator of transcription') family constitute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune system. Research on this paradigmatic pathway has experienced brea...

journal_title：Nature immunology

authors： Villarino AV,Kanno Y,O'Shea JJ

更新日期：2017-03-22 00:00:00

abstract：:We evaluated changes in the signaling potentials and proliferative capacity of single antigen-specific T helper (TH) cells during a primary immune response to a protein antigen. At the peak of cellular expansion in vivo all antigen-specific TH cells exhibited a profound block in CD3- and CD4-mediated mobilization of i...

journal_title：Nature immunology

authors： Bikah G,Pogue-Caley RR,McHeyzer-Williams LJ,McHeyzer-Williams MG

更新日期：2000-11-01 00:00:00

abstract：:Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-d...

journal_title：Nature immunology

authors： Ilarregui JM,Croci DO,Bianco GA,Toscano MA,Salatino M,Vermeulen ME,Geffner JR,Rabinovich GA

更新日期：2009-09-01 00:00:00

abstract：:Susceptibility to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by a variety of genetic and environmental or stochastic factors. After over a decade of linkage analyses, the identification of non-major histocompatibility complex (non-MHC) susceptibility alleles has proved to be difficult, predo...

journal_title：Nature immunology

authors： Wandstrat A,Wakeland E

更新日期：2001-09-01 00:00:00

abstract：:T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of ...

journal_title：Nature immunology

authors： Kallies A,Hawkins ED,Belz GT,Metcalf D,Hommel M,Corcoran LM,Hodgkin PD,Nutt SL

更新日期：2006-05-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) develop from progenitor thymocytes after the engagement of T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular mechanisms are still unclear. Here we show that the Nr4a nuclear receptors, which are encoded by immediate-early genes upregulated by TCR...

journal_title：Nature immunology

authors： Sekiya T,Kashiwagi I,Yoshida R,Fukaya T,Morita R,Kimura A,Ichinose H,Metzger D,Chambon P,Yoshimura A

更新日期：2013-03-01 00:00:00

abstract：:The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire's specificity, we performed single-cell RNA-seq and DNA-methylation analysis of Aire-suffi...

journal_title：Nature immunology

authors： Meredith M,Zemmour D,Mathis D,Benoist C

更新日期：2015-09-01 00:00:00

abstract：:Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...

journal_title：Nature immunology

authors： Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

更新日期：2012-10-01 00:00:00

abstract：:Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...

journal_title：Nature immunology

authors： Safronova A,Araujo A,Camanzo ET,Moon TJ,Elliott MR,Beiting DP,Yarovinsky F

更新日期：2019-01-01 00:00:00

abstract：:Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression...

journal_title：Nature immunology

authors： Seiler MP,Mathew R,Liszewski MK,Spooner CJ,Barr K,Meng F,Singh H,Bendelac A

更新日期：2012-02-05 00:00:00

abstract：:The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influx in naive T lymphocytes is unknown. Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of na...

journal_title：Nature immunology

authors： Jha MK,Badou A,Meissner M,McRory JE,Freichel M,Flockerzi V,Flavell RA

更新日期：2009-12-01 00:00:00

abstract：:Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c...

journal_title：Nature immunology

authors： Belyaev NN,Brown DE,Diaz AI,Rae A,Jarra W,Thompson J,Langhorne J,Potocnik AJ

更新日期：2010-06-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Soveg F,von Moltke J,Savan R

更新日期：2019-02-01 00:00:00

abstract：:Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes, exposing the metabolic and protein synthesis machiner...

journal_title：Nature immunology

authors： Howden AJM,Hukelmann JL,Brenes A,Spinelli L,Sinclair LV,Lamond AI,Cantrell DA

更新日期：2019-11-01 00:00:00