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A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.

Abstract：

:PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Okazaki T,Chikuma S,Iwai Y,Fagarasan S,Honjo T

doi

10.1038/ni.2762

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1212-8

issue

12

eissn

1529-2908

issn

1529-2916

pii

ni.2762

journal_volume

14

pub_type

杂志文章,评审

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