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The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.

Abstract：

:The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR negatively regulates the Cd8 loci during the transition to the double-positive (DP) stage. Moreover, loss of MAZR led to partial redirection of major histocompatibility complex (MHC) class I-restricted thymocytes into CD4(+) helper-like T cells, which correlated with derepression of Th-POK, a central transcription factor for helper-lineage development. MAZR bound the silencer of the gene encoding Th-POK, which indicated direct regulation of this locus by MAZR. Thus, MAZR is part of the transcription factor network that regulates the CD8 lineage differentiation of DP thymocytes.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Sakaguchi S,Hombauer M,Bilic I,Naoe Y,Schebesta A,Taniuchi I,Ellmeier W

doi

10.1038/ni.1860

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

442-8

issue

5

eissn

1529-2908

issn

1529-2916

pii

ni.1860

journal_volume

11

pub_type

杂志文章

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