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Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.

Abstract：

:Dendritic cells (DCs) initiate and regulate immunity against foreign and self antigens. Here we identified more than 200 individual major histocompatibility complex class II-associated peptides on human DCs and found that mature DCs selectively upregulated the self peptide CLIP. CLIP cosegregated together with foreign antigenic peptides in tetraspan microdomains on the surface and localized to DC-T cell synapses. The increased representation of CLIP-major histocompatibility complex class II complexes favored polarization of autologous naive T cells toward the nonpolarized and T helper type 2 (T(H)2) phenotype. There was also a considerably higher T(H)2/T(H)1 ratio in H2-DM-deficient mice, which have a CLIP(hi) phenotype, in contrast to wild-type, CLIP(lo) mice. Thus, the self peptide CLIP on DCs qualifies as an endogenous regulator in priming of T helper cells by antagonizing the polarization toward the T(H)1 phenotype.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Röhn TA,Boes M,Wolters D,Spindeldreher S,Müller B,Langen H,Ploegh H,Vogt AB,Kropshofer H

doi

10.1038/ni1108

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

909-18

issue

9

eissn

1529-2908

issn

1529-2916

pii

ni1108

journal_volume

5

pub_type

杂志文章

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