Abstract:
:Mutational spectra analysis of 15 immunoglobulin genes suggested that consensus motifs RGYW and WA were universal descriptors of somatic hypermutation. Highly mutable sites, "hotspots", that matched WA were preferentially found in one DNA strand and RGYW hotspots were found in both strands. Analysis of base-substitution hotspots in DNA polymerase error spectra showed that 33 of 36 hotspots in the human polymerase eta spectrum conformed to the WA consensus. This and four other characteristics of polymerase eta substitution specificity suggest that errors introduced by this enzyme during synthesis of the nontranscribed DNA strand in variable regions may contribute to strand-specific somatic hypermutagenesis of immunoglobulin genes at A-T base pairs.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Rogozin IB,Pavlov YI,Bebenek K,Matsuda T,Kunkel TAdoi
10.1038/88732keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
530-6issue
6eissn
1529-2908issn
1529-2916pii
88732journal_volume
2pub_type
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