Abstract:
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journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Roquilly A,Jacqueline C,Davieau M,Mollé A,Sadek A,Fourgeux C,Rooze P,Broquet A,Misme-Aucouturier B,Chaumette T,Vourc'h M,Cinotti R,Marec N,Gauttier V,McWilliam HEG,Altare F,Poschmann J,Villadangos JA,Asehnoune Kdoi
10.1038/s41590-020-0739-9subject
Has Abstractpub_date
2020-08-01 00:00:00pages
962issue
8eissn
1529-2908issn
1529-2916pii
10.1038/s41590-020-0739-9journal_volume
21pub_type
已发布勘误abstract::Xenogeneic tissues induce vigorous T cell immunity, reflecting the ability of costimulatory molecules to function across species barriers. We describe a strategy to inhibit costimulation that exploits species differences using the model of porcine pancreatic islet transplantation into mice. Mice were immunized with ch...
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abstract::The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire(+) mTECs, however, are not well understood. Here we demonstrate that the tight-junction components claudin-3 and ...
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abstract::Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...
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abstract::We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naïve CD8 T cells, natural killer T cells...
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abstract::Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell receptor internalizat...
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abstract::The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...
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abstract:: ...
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