Apoptosis in the development and maintenance of the immune system.

abstract：:High-throughput 3' single-cell RNA-sequencing (scRNA-seq) allows cost-effective, detailed characterization of individual immune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including variable sequences of T cell antigen receptors (TCRs) that...

journal_title：Nature immunology

authors： Tu AA,Gierahn TM,Monian B,Morgan DM,Mehta NK,Ruiter B,Shreffler WG,Shalek AK,Love JC

更新日期：2019-12-01 00:00:00

abstract：:Regenerative stem cell-like memory (TSCM) CD8+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing...

journal_title：Nature immunology

authors： Verma V,Jafarzadeh N,Boi S,Kundu S,Jiang Z,Fan Y,Lopez J,Nandre R,Zeng P,Alolaqi F,Ahmad S,Gaur P,Barry ST,Valge-Archer VE,Smith PD,Banchereau J,Mkrtichyan M,Youngblood B,Rodriguez PC,Gupta S,Khleif SN

更新日期：2021-01-01 00:00:00

abstract：:B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in hum...

journal_title：Nature immunology

authors： Burrows N,Bashford-Rogers RJM,Bhute VJ,Peñalver A,Ferdinand JR,Stewart BJ,Smith JEG,Deobagkar-Lele M,Giudice G,Connor TM,Inaba A,Bergamaschi L,Smith S,Tran MGB,Petsalaki E,Lyons PA,Espeli M,Huntly BJP,Smith KGC,Corn

更新日期：2020-11-01 00:00:00

abstract：:Cytosolic detection of pathogen-derived nucleic acids is critical for the initiation of innate immune defense against diverse bacterial, viral and eukaryotic pathogens. Conversely, inappropriate responses to cytosolic nucleic acids can produce severe autoimmune pathology. The host protein STING has been identified as ...

journal_title：Nature immunology

authors： Burdette DL,Vance RE

更新日期：2013-01-01 00:00:00

abstract：:The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cell...

journal_title：Nature immunology

authors： Delconte RB,Kolesnik TB,Dagley LF,Rautela J,Shi W,Putz EM,Stannard K,Zhang JG,Teh C,Firth M,Ushiki T,Andoniou CE,Degli-Esposti MA,Sharp PP,Sanvitale CE,Infusini G,Liau NP,Linossi EM,Burns CJ,Carotta S,Gray DH,Se

更新日期：2016-07-01 00:00:00

abstract：:Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how the functional integrity of Treg cells is maintained under activating environments is unclear. Here we show that autophagy is active in Treg cells and supports their lineage stability and survival fitness. Treg c...

journal_title：Nature immunology

authors： Wei J,Long L,Yang K,Guy C,Shrestha S,Chen Z,Wu C,Vogel P,Neale G,Green DR,Chi H

更新日期：2016-03-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Mastellos DC,Blom AM,Connolly ES,Daha MR,Geisbrecht BV,Ghebrehiwet B,Gros P,Hajishengallis G,Holers VM,Huber-Lang M,Kinoshita T,Mollnes TE,Montgomery RA,Morgan BP,Nilsson B,Pio R,Ricklin D,Risitano AM,Taylor RP,Mant

更新日期：2019-11-01 00:00:00

abstract：:The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transducti...

journal_title：Nature immunology

authors： Liu X,Bosselut R

更新日期：2004-03-01 00:00:00

abstract：:The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was p...

journal_title：Nature immunology

authors： Turville SG,Cameron PU,Handley A,Lin G,Pöhlmann S,Doms RW,Cunningham AL

更新日期：2002-10-01 00:00:00

abstract：:The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hyperm...

journal_title：Nature immunology

authors： Manis JP,Morales JC,Xia Z,Kutok JL,Alt FW,Carpenter PB

更新日期：2004-05-01 00:00:00

abstract：:The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxi...

journal_title：Nature immunology

authors： Yuk JM,Shin DM,Lee HM,Kim JJ,Kim SW,Jin HS,Yang CS,Park KA,Chanda D,Kim DK,Huang SM,Lee SK,Lee CH,Kim JM,Song CH,Lee SY,Hur GM,Moore DD,Choi HS,Jo EK

更新日期：2011-07-03 00:00:00

abstract：:The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived fro...

journal_title：Nature immunology

authors： Miller MS,Rialdi A,Ho JS,Tilove M,Martinez-Gil L,Moshkina NP,Peralta Z,Noel J,Melegari C,Maestre AM,Mitsopoulos P,Madrenas J,Heinz S,Benner C,Young JA,Feagins AR,Basler CF,Fernandez-Sesma A,Becherel OJ,Lavin MF,va

更新日期：2015-05-01 00:00:00

abstract：:As a result of decades of research-driven breakthroughs in basic and clinical science and recent advances in the broad-scale implementation of interventions for the prevention and treatment of infection with HIV, a turning point has been reached in the global HIV-AIDS pandemic. To end the pandemic and achieve the goal...

journal_title：Nature immunology

authors： Fauci AS,Folkers GK,Dieffenbach CW

更新日期：2013-11-01 00:00:00

abstract：:Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR)...

journal_title：Nature immunology

authors： Quann EJ,Liu X,Altan-Bonnet G,Huse M

更新日期：2011-05-22 00:00:00

abstract：:Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal transducer and activator of transcription') family constitute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune system. Research on this paradigmatic pathway has experienced brea...

journal_title：Nature immunology

authors： Villarino AV,Kanno Y,O'Shea JJ

更新日期：2017-03-22 00:00:00

abstract：:Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In add...

journal_title：Nature immunology

authors： Shibutani ST,Saitoh T,Nowag H,Münz C,Yoshimori T

更新日期：2015-10-01 00:00:00

abstract：:We evaluated changes in the signaling potentials and proliferative capacity of single antigen-specific T helper (TH) cells during a primary immune response to a protein antigen. At the peak of cellular expansion in vivo all antigen-specific TH cells exhibited a profound block in CD3- and CD4-mediated mobilization of i...

journal_title：Nature immunology

authors： Bikah G,Pogue-Caley RR,McHeyzer-Williams LJ,McHeyzer-Williams MG

更新日期：2000-11-01 00:00:00

abstract：:Toll-like receptor (TLR) signaling activates the inhibitor of transcription factor NF-κB (IκB) kinase (IKK) complex, which governs NF-κB-mediated transcription during inflammation. The RNase regnase-1 serves a critical role in preventing autoimmunity by controlling the stability of mRNAs that encode cytokines. Here we...

journal_title：Nature immunology

authors： Iwasaki H,Takeuchi O,Teraguchi S,Matsushita K,Uehata T,Kuniyoshi K,Satoh T,Saitoh T,Matsushita M,Standley DM,Akira S

更新日期：2011-10-30 00:00:00

abstract：:The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functio...

journal_title：Nature immunology

authors： Luis TC,Luc S,Mizukami T,Boukarabila H,Thongjuea S,Woll PS,Azzoni E,Giustacchini A,Lutteropp M,Bouriez-Jones T,Vaidya H,Mead AJ,Atkinson D,Böiers C,Carrelha J,Macaulay IC,Patient R,Geissmann F,Nerlov C,Sandberg R,

更新日期：2016-12-01 00:00:00

abstract：:Helper T cells control host defense against pathogens. The receptors for interleukin 12 (IL-12), IL-4 and IL-6 are required for differentiation into the T(H)1, T(H)2 and T(H)17 subsets of helper T cells, respectively. IL-2 signaling via the transcription factor STAT5 controls T(H)2 differentiation by regulating both t...

journal_title：Nature immunology

authors： Liao W,Lin JX,Wang L,Li P,Leonard WJ

更新日期：2011-06-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population resp...

journal_title：Nature immunology

authors： Huang Y,Guo L,Qiu J,Chen X,Hu-Li J,Siebenlist U,Williamson PR,Urban JF Jr,Paul WE

更新日期：2015-02-01 00:00:00

abstract：:While a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed en...

journal_title：Nature immunology

authors： Saini AS,Shenoy GN,Rath S,Bal V,George A

更新日期：2014-03-01 00:00:00

abstract：:Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...

journal_title：Nature immunology

authors： Abarrategui I,Krangel MS

更新日期：2006-10-01 00:00:00

abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

journal_title：Nature immunology

authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

更新日期：2005-08-01 00:00:00

abstract：:The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoi...

journal_title：Nature immunology

authors： van de Pavert SA,Olivier BJ,Goverse G,Vondenhoff MF,Greuter M,Beke P,Kusser K,Höpken UE,Lipp M,Niederreither K,Blomhoff R,Sitnik K,Agace WW,Randall TD,de Jonge WJ,Mebius RE

更新日期：2009-11-01 00:00:00

abstract：:The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this di...

journal_title：Nature immunology

authors： Colucci F,Di Santo JP,Leibson PJ

更新日期：2002-09-01 00:00:00

abstract：:Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test whether loss of Nedd4 affects T cells in the same way, we generated Nedd4(+/+) and Nedd4(-/-) fetal l...

journal_title：Nature immunology

authors： Yang B,Gay DL,MacLeod MK,Cao X,Hala T,Sweezer EM,Kappler J,Marrack P,Oliver PM

更新日期：2008-12-01 00:00:00

abstract：:Stimulation of Toll-like receptors (TLRs) initiates potent innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by the TLR3 ligand double-stran...

journal_title：Nature immunology

authors： Meylan E,Burns K,Hofmann K,Blancheteau V,Martinon F,Kelliher M,Tschopp J

更新日期：2004-05-01 00:00:00

abstract：:Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) in lymphocytes triggers the release of Ca2+ from intracellular stores; this release of Ca2+ results in the opening of store-operated Ca2+ channels in the plasma membrane. Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb)...

journal_title：Nature immunology

authors： Miller AT,Sandberg M,Huang YH,Young M,Sutton S,Sauer K,Cooke MP

更新日期：2007-05-01 00:00:00

abstract：:In the version of this article initially published, the label (CASP4-C285A-HA) above the second and fifth lanes in the right blot in Fig. 1e is incorrect; the correct label is CASP4-C258A-HA. Also, the two labels at right above the plot in Fig. 6c were switched; the far right label should be 'Co-housed Serpinb1a-/-' (...

journal_title：Nature immunology

authors： Choi YJ,Kim S,Choi Y,Nielsen TB,Yan J,Lu A,Ruan J,Lee HR,Wu H,Spellberg B,Jung JU

更新日期：2019-05-01 00:00:00