Abstract:
:Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo and contributed to the expulsion of Nippostrongylus brasiliensis. They also acquired IL-17-producing ability and provided partial protection against Candida albicans. We propose that iILC2 cells are transient progenitors of ILCs mobilized by inflammation and infection that develop into nILC2-like cells or ILC3-like cells and contribute to immunity to both helminths and fungi.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Huang Y,Guo L,Qiu J,Chen X,Hu-Li J,Siebenlist U,Williamson PR,Urban JF Jr,Paul WEdoi
10.1038/ni.3078subject
Has Abstractpub_date
2015-02-01 00:00:00pages
161-9issue
2eissn
1529-2908issn
1529-2916pii
ni.3078journal_volume
16pub_type
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更新日期:2008-08-01 00:00:00
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更新日期:2013-05-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
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pub_type:
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更新日期:2010-09-01 00:00:00
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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