Abstract:
:Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which are crucial in generating and maintaining immune responses, represent a target for CMV and that the transient, but profound, immunosuppression that accompanies CMV infection results from viral interference with DC functions. Here we show that DCs were permissive to murine CMV infection. In addition, DC infection prevented delivery of the signals required for T cell activation. Thus, CMV-mediated impairment of DC function may be crucial for virally induced immunosuppression and interleukin 2 is implicated as a key factor.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Andrews DM,Andoniou CE,Granucci F,Ricciardi-Castagnoli P,Degli-Esposti MAdoi
10.1038/ni724keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
1077-84issue
11eissn
1529-2908issn
1529-2916pii
ni724journal_volume
2pub_type
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