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Multiple layers of B cell memory with different effector functions.

Abstract：

:Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a particulate antigen, B cell memory appeared in several subsets, comprising clusters of immunoglobulin M-positive (IgM(+)) and IgG1(+) B cells in germinal center-like structures that persisted up to 8 months after immunization, as well as IgM(+) and IgG1(+) B cells with a memory phenotype outside of B cell follicles. After challenge, the IgG subset differentiated into plasmocytes, whereas the IgM subset reinitiated a germinal center reaction. This model, in which B cell memory appears in several layers with different functions, reconciles previous conflicting propositions.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Dogan I,Bertocci B,Vilmont V,Delbos F,Mégret J,Storck S,Reynaud CA,Weill JC

doi

10.1038/ni.1814

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1292-9

issue

12

eissn

1529-2908

issn

1529-2916

pii

ni.1814

journal_volume

10

pub_type

杂志文章

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