Abstract：
:Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7Ralpha) emerged that had both lymphoid and myeloid potential in vitro. After being transferred into uninfected alymphoid or malaria-infected hosts, IL-7Ralpha(+)c-Kit(hi) progenitors generated mainly myeloid cells that contributed to the clearance of infected erythrocytes in infected hosts. The generation of these infection-induced progenitors was critically dependent on interferon-gamma (IFN-gamma) signaling in hematopoietic progenitors. Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Belyaev NN,Brown DE,Diaz AI,Rae A,Jarra W,Thompson J,Langhorne J,Potocnik AJdoi
10.1038/ni.1869subject
Has Abstractpub_date
2010-06-01 00:00:00pages
477-85issue
6eissn
1529-2908issn
1529-2916pii
ni.1869journal_volume
11pub_type
杂志文章abstract：:High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA sensing in tumor cells after radiation is rather limited. Here we demonstrate that irradiated tumor cells hijack caspase 9 signaling to suppress intrinsic DNA sensi...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0641-5
更新日期：2020-05-01 00:00:00
abstract：:The kappa intronic (MiE(kappa)) and 3' (3'E(kappa)) enhancers are both quantitatively important to, but not essential for, immunoglobulin kappa rearrangement. To determine the functional redundancy between these two enhancers, B cells derived from mutant embryonic stem cells--in which both MiE(kappa) and 3'E(kappa) we...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni790
更新日期：2002-05-01 00:00:00
abstract：:Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to i...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/87766
更新日期：2001-05-01 00:00:00
abstract：:The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni922
更新日期：2003-05-01 00:00:00
abstract：:The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015. ...
journal_title：Nature immunology
pub_type：
doi：10.1038/ni.3367
更新日期：2016-03-01 00:00:00
abstract：:T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects....
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1351
更新日期：2006-07-01 00:00:00
abstract：:In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article. ...
journal_title：Nature immunology
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41590-018-0104-4
更新日期：2018-06-01 00:00:00
abstract：:Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1814
更新日期：2009-12-01 00:00:00
abstract：:High-throughput 3' single-cell RNA-sequencing (scRNA-seq) allows cost-effective, detailed characterization of individual immune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including variable sequences of T cell antigen receptors (TCRs) that...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0544-5
更新日期：2019-12-01 00:00:00
abstract：:Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response vi...
journal_title：Nature immunology
pub_type： 历史文章,杂志文章
doi：10.1038/ni0208-113
更新日期：2008-02-01 00:00:00
abstract：:Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B(-/-) mice had an increased number of peritoneal B1 cells. Splenic PIR-B(-/-) B2 cells were constitutively activated and proliferated much more than th...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni801
更新日期：2002-06-01 00:00:00
abstract：:The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the production of autoantibodies against post-translationally modified proteins (checkpoint 1). After years of asymptomatic autoimmunity and progressive immune system remodeling, tissue tolerance erodes and joint inflammation ensues as t...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/s41590-020-00816-x
更新日期：2021-01-01 00:00:00
abstract：:The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, pr...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni907
更新日期：2003-04-01 00:00:00
abstract：:Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of path...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.2406
更新日期：2012-10-01 00:00:00
abstract：:Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphata...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1623
更新日期：2008-07-01 00:00:00
abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of ...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/s41590-017-0022-x
更新日期：2018-02-01 00:00:00
abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1226
更新日期：2005-08-01 00:00:00
abstract：:B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in hum...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0772-8
更新日期：2020-11-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0282-0
更新日期：2019-01-01 00:00:00
abstract：:We define here the specificity and significance of proteases in the endoplasmic reticulum (ER) that generate peptides for presentation by major histocompatibility complex (MHC) class I molecules. We show that aminopeptidases efficiently trimmed all residues except proline that flank the NH2-termini of antigenic precur...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/89800
更新日期：2001-07-01 00:00:00
abstract：:Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3053
更新日期：2015-02-01 00:00:00
abstract：:Cooperation between different innate signaling pathways induced by pattern-recognition receptors (PRRs) on dendritic cells (DCs) is crucial for tailoring adaptive immunity to pathogens. Here we show that carbohydrate-specific signaling through the C-type lectin DC-SIGN tailored cytokine production in response to disti...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1778
更新日期：2009-10-01 00:00:00
abstract：:In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2981
更新日期：2014-10-01 00:00:00
abstract：:We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the widely expressed human MDM2 oncoprotein and were able to bypass self-tolerance to this tumor antigen in HLA-A*0201 (A2.1) transgenic mice and by generating A2.1-negative, allo-A2.1-restricted human T lymphocytes. A broad range of ma...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1001-962
更新日期：2001-10-01 00:00:00
abstract：:Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population resp...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3078
更新日期：2015-02-01 00:00:00
abstract：:The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor ty...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1682
更新日期：2009-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) exert powerful effects on immunological function by tuning networks of target genes that orchestrate cell activity. We sought to identify miRNAs and miRNA-regulated pathways that control the type 2 helper T cell (TH2 cell) responses that drive pathogenic inflammation in asthma. Profiling miRNA expre...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3026
更新日期：2014-12-01 00:00:00
abstract：:Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonst...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1983
更新日期：2011-02-01 00:00:00
abstract：:Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes, exposing the metabolic and protein synthesis machiner...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0495-x
更新日期：2019-11-01 00:00:00
abstract：:Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1187
更新日期：2005-05-01 00:00:00
