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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.

Abstract：

:The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, providing an integral link between XBP-1, the UPR and plasma cell differentiation. Signals involved in plasma cell differentiation, specifically interleukin-4, control the transcription of XBP-1, whereas its post-transcriptional processing is dependent on synthesis of immunoglobulins during B cell differentiation. We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Iwakoshi NN,Lee AH,Vallabhajosyula P,Otipoby KL,Rajewsky K,Glimcher LH

doi

10.1038/ni907

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

321-9

issue

4

eissn

1529-2908

issn

1529-2916

pii

ni907

journal_volume

4

pub_type

杂志文章

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