Abstract:
:This corrects the article DOI: 10.1038/ni.3713.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JMdoi
10.1038/ni1117-1271csubject
Has Abstractpub_date
2017-10-18 00:00:00pages
1271issue
11eissn
1529-2908issn
1529-2916pii
ni1117-1271cjournal_volume
18pub_type
杂志文章,已发布勘误abstract::The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire's specificity, we performed single-cell RNA-seq and DNA-methylation analysis of Aire-suffi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3247
更新日期:2015-09-01 00:00:00
abstract::CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses are not understood. We show here that T cell recognition of glucose monomycolate antigens with long (C(80)) alkyl chains involves the delivery of CD1b proteins an...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni780
更新日期:2002-05-01 00:00:00
abstract::Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3324
更新日期:2016-01-01 00:00:00
abstract::Toll-like receptors (TLRs) are key initiators of the innate immune response and promote adaptive immunity. Much has been learned about the role of TLRs in human immunity from studies linking TLR genetic variation with disease. First, monogenic disorders associated with complete deficiency in certain TLR pathways, such...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2284
更新日期:2012-05-18 00:00:00
abstract::Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/87766
更新日期:2001-05-01 00:00:00
abstract::T cell exhaustion has a major role in failure to control chronic infection. High expression of inhibitory receptors, including PD-1, and the inability to sustain functional T cell responses contribute to exhaustion. However, the transcriptional control of these processes remains unclear. Here we demonstrate that the t...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2046
更新日期:2011-05-29 00:00:00
abstract::Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2570
更新日期:2013-05-01 00:00:00
abstract::The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the production of autoantibodies against post-translationally modified proteins (checkpoint 1). After years of asymptomatic autoimmunity and progressive immune system remodeling, tissue tolerance erodes and joint inflammation ensues as t...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/s41590-020-00816-x
更新日期:2021-01-01 00:00:00
abstract::Store-operated Ca2+ entry through calcium release-activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in immune cells. Here we show that mouse T cells and fibroblasts lacking the calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sen...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1574
更新日期:2008-04-01 00:00:00
abstract::Xenogeneic tissues induce vigorous T cell immunity, reflecting the ability of costimulatory molecules to function across species barriers. We describe a strategy to inhibit costimulation that exploits species differences using the model of porcine pancreatic islet transplantation into mice. Mice were immunized with ch...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/77853
更新日期:2000-08-01 00:00:00
abstract::The complex heterogeneity of cells, and their interconnectedness with each other, are major challenges to identifying clinically relevant measurements that reflect the state and capability of the immune system. Highly multiplexed, single-cell technologies may be critical for identifying correlates of disease or immuno...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2796
更新日期:2014-02-01 00:00:00
abstract::High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell-dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4-reporter system, we show here that CD4(+) foll...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1715
更新日期:2009-04-01 00:00:00
abstract::Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells (DCs) and macrophages. Because there is no precedent for immune receptor signaling in the ER, we investigated how TLR9 is act...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1028
更新日期:2004-02-01 00:00:00
abstract::CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release-activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combined immunodeficiency disease in humans. Here we generated CRACM1-deficient mice in which beta-galactosidase activity 'reporte...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1550
更新日期:2008-01-01 00:00:00
abstract::T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects....
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1351
更新日期:2006-07-01 00:00:00
abstract::Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-re...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0430-1
更新日期:2019-08-01 00:00:00
abstract::Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1187
更新日期:2005-05-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 评论,杂志文章
doi:10.1038/s41590-018-0302-0
更新日期:2019-02-01 00:00:00
abstract::Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni910
更新日期:2003-05-01 00:00:00
abstract::Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditions that allow the stimulatory presentation of self peptides themselves and that this might suffice to elicit autoreactive T ce...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3512
更新日期:2016-09-01 00:00:00
abstract::In neutrophils, superoxide anion production generally accompanies chemotaxis and functions in killing invading pathogens. The GIT2 GTPase-activating protein binds to the guanine nucleotide-exchange factor alphaPIX. Here we show that GIT2 was necessary for directional chemotaxis and for the suppression of superoxide pr...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1349
更新日期:2006-07-01 00:00:00
abstract::Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1379
更新日期:2006-10-01 00:00:00
abstract::Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threa...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-00826-9
更新日期:2021-01-01 00:00:00
abstract::Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0250-8
更新日期:2019-01-01 00:00:00
abstract::As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni0407-325
更新日期:2007-04-01 00:00:00
abstract::The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential role in supporting ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2833
更新日期:2014-04-01 00:00:00
abstract::Myelin basic protein-specific CD8(+) T cells can induce central nervous system autoimmunity; however, immune tolerance prevents these autoreactive cells from causing disease. To define the mechanisms that mediate tolerance, we developed two T cell receptor-transgenic mouse lines with different affinities for the H-2K(...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1073
更新日期:2004-06-01 00:00:00
abstract::Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of the chemokine receptor CXCRI was found to stimulate rapid formation of beta-arrestin complexes with Hck or c-Fgr. Formation o...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/79767
更新日期:2000-09-01 00:00:00
abstract::PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastati...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2762
更新日期:2013-12-01 00:00:00
abstract::Genes and pathways in which inactivation dampens tissue inflammation present new opportunities for understanding the pathogenesis of common human inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. We identified a mutation in the gene encoding the deubiquitination ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3581
更新日期:2017-01-01 00:00:00