Abstract:
:Xenogeneic tissues induce vigorous T cell immunity, reflecting the ability of costimulatory molecules to function across species barriers. We describe a strategy to inhibit costimulation that exploits species differences using the model of porcine pancreatic islet transplantation into mice. Mice were immunized with chimeric peptides that contained a known T cell epitope and selected sequences of the porcine costimulatory molecule CD86. This resulted in anti-peptide antibody responses that recognized intact porcine CD86, blocked costimulation by porcine CD86 but not murine CD86 in vitro, and prolonged the survival of porcine islet grafts in vivo. This strategy of inducing endogenous donor-specific costimulatory blockade has potential clinical applicability.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Rogers NJ,Mirenda V,Jackson I,Dorling A,Lechler RIdoi
10.1038/77853keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
163-8issue
2eissn
1529-2908issn
1529-2916pii
77853journal_volume
1pub_type
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