Abstract：
:CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. We used mice that were transgenic for one of two human CD46 isoforms that differ in their cytoplasmic domains (termed CD46-1 and CD46-2) to analyze the effect of CD46 stimulation on the immune response. We show here that CD46 can regulate inflammatory responses, either by inhibiting (CD46-1) or increasing (CD46-2) the contact hypersensitivity reaction. We found that engagement of CD46-1 or CD46-2 differentially affected CD8(+) T cell cytotoxicity, CD4(+) T cell proliferation, interleukin 2 (IL-2) and IL-10 production as well as tyrosine phosphorylation of Vav in T lymphocytes. These results indicate that CD46 plays a role in regulating the T cell induced inflammatory reaction and in fine-tuning the cellular immune response by bridging innate and acquired immunity.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Marie JC,Astier AL,Rivailler P,Rabourdin-Combe C,Wild TF,Horvat Bdoi
10.1038/ni810keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
659-66issue
7eissn
1529-2908issn
1529-2916pii
ni810journal_volume
3pub_type
杂志文章abstract：:Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni0901-842
更新日期：2001-09-01 00:00:00
abstract：:DAP12-coupled receptors influence signals emanating from Toll-like receptors, integrins and receptors for cytokines and growth factors. New findings indicate that DAP12 also facilitates the ability of CSF-1R, the receptor for M-CSF, to induce the stabilization and nuclear translocation of beta-catenin. ...
journal_title：Nature immunology
pub_type： 新闻
doi：10.1038/ni0709-681
更新日期：2009-07-01 00:00:00
abstract：:Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to i...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/87766
更新日期：2001-05-01 00:00:00
abstract：:The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion w...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1288
更新日期：2006-01-01 00:00:00
abstract：:Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an in...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.2018
更新日期：2011-06-01 00:00:00
abstract：:Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In add...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.3273
更新日期：2015-10-01 00:00:00
abstract：:The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was p...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni841
更新日期：2002-10-01 00:00:00
abstract：:Transcription factors of the NF-kappaB family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-kappaB activation is cytoplasmic and leads to the release of NF-kappaB proteins from IkappaB molecules, specific inhibitors that prevent their nuclear accumulation. However, it is be...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni1196
更新日期：2005-05-01 00:00:00
abstract：:Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1379
更新日期：2006-10-01 00:00:00
abstract：:The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and immune regulation. Although Qa-1 has been linked to CD8 T cell-dependent suppression, the physiological relevance of this observation is unclear. We generated mice deficient in Qa-1 to develop an understanding of this process. Qa-1-...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1063
更新日期：2004-05-01 00:00:00
abstract：:Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentrations. Here we show that the conditional deletion o...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni892
更新日期：2003-03-01 00:00:00
abstract：:The importance of protein glycosylation in the migration of immune cells throughout the body has been extensively appreciated. However, our awareness of the impact of glycosylation on the regulation of innate and adaptive immune responses is relatively new. An increasing number of studies reveal the relevance of glyco...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.f.203
更新日期：2008-06-01 00:00:00
abstract：:Antibody specificity and diversity is generated in B cells during germinal center maturation through clonal expansion while they undergo class-switch recombination and somatic hypermutation. Here we demonstrate that the transcriptional repressor Bcl-6 mediates this phenotype by directly repressing ATR in centroblasts ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1478
更新日期：2007-07-01 00:00:00
abstract：:Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3053
更新日期：2015-02-01 00:00:00
abstract：:The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic insufficiency can imprint permanent T cell dysfunction. We found that TILs accumulated depolarized mitochondria as a res...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0793-3
更新日期：2020-12-01 00:00:00
abstract：:Immunological reactions are propelled by ever-changing signals that alter the translational ability of the RNA in the cells involved. Such alterations are considered to be consequential modifications in the transcriptomic decoding of the genetic blueprint. The identification of RNA-binding protein (RBP) assemblies eng...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.2884
更新日期：2014-06-01 00:00:00
abstract：:CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane. CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD). Here we investigated the role of CARMA1 in T cell act...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni830
更新日期：2002-09-01 00:00:00
abstract：:After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1559
更新日期：2008-03-01 00:00:00
abstract：:Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0250-8
更新日期：2019-01-01 00:00:00
abstract：:The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-posit...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1123
更新日期：2004-11-01 00:00:00
abstract：:CD8+ T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the molecular mechanisms by which CD8+ T cells are triggered to enter an exhausted state remain unclear. Here, we show that interleukin-2 (IL-2) acts as an environmental cue t...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-00850-9
更新日期：2021-01-11 00:00:00
abstract：:The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibility was identified early in the pandemic, with a major role attr...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.3147
更新日期：2015-06-01 00:00:00
abstract：:Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni1201-1103
更新日期：2001-12-01 00:00:00
abstract：:Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditions that allow the stimulatory presentation of self peptides themselves and that this might suffice to elicit autoreactive T ce...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3512
更新日期：2016-09-01 00:00:00
abstract：:PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastati...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.2762
更新日期：2013-12-01 00:00:00
abstract：:Regenerative stem cell-like memory (TSCM) CD8+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-00818-9
更新日期：2021-01-01 00:00:00
abstract：:Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylation, a protein post-transl...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3487
更新日期：2016-08-01 00:00:00
abstract：:Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population resp...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3078
更新日期：2015-02-01 00:00:00
abstract：:We have identified a silencer and an antisilencing element that interact at a distance of 85 kilobases to regulate expression of the recombination activating genes Rag1 and Rag2 in thymocytes. Transgenic experiments showed that Rag promoter-proximal cis elements directed tissue-specific expression and that a Runx-depe...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1053
更新日期：2004-04-01 00:00:00
abstract：:The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015. ...
journal_title：Nature immunology
pub_type：
doi：10.1038/ni.3367
更新日期：2016-03-01 00:00:00
