Abstract:
:CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. We used mice that were transgenic for one of two human CD46 isoforms that differ in their cytoplasmic domains (termed CD46-1 and CD46-2) to analyze the effect of CD46 stimulation on the immune response. We show here that CD46 can regulate inflammatory responses, either by inhibiting (CD46-1) or increasing (CD46-2) the contact hypersensitivity reaction. We found that engagement of CD46-1 or CD46-2 differentially affected CD8(+) T cell cytotoxicity, CD4(+) T cell proliferation, interleukin 2 (IL-2) and IL-10 production as well as tyrosine phosphorylation of Vav in T lymphocytes. These results indicate that CD46 plays a role in regulating the T cell induced inflammatory reaction and in fine-tuning the cellular immune response by bridging innate and acquired immunity.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Marie JC,Astier AL,Rivailler P,Rabourdin-Combe C,Wild TF,Horvat Bdoi
10.1038/ni810keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
659-66issue
7eissn
1529-2908issn
1529-2916pii
ni810journal_volume
3pub_type
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