Abstract:
:A transgenic reporter mouse strain, which expressed the human CD25 (hCD25) surface marker as a reporter under the control of the pre-T cell receptor alpha(pTalpha) promoter, was used to identify lymphoid precursors that expressed pTalpha intracellularly. The hCD25 reporter marked intra- and extrathymic precursors of lymphocytes but not myeloid cells. The earliest intrathymic precursors were CD4(lo)CD8(-)CD25(-)CD44(+)c-Kit(+) cells that expressed elevated levels of Notch-1 mRNA. Clonogenic assays showed that the extrathymic precursors were common lymphoid progenitors (CLPs) that included CD19(-), B220(+), Thy1(+) and CD4(+) cells. Thus, the pTalpha reporter can be used to trace lymphopoiesis between CLPs and alphabeta T cells. The slower extinction of the hCD25 reporter compared to pTalpha enabled us to define points at which pTalpha(-) lineages branched off.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Gounari F,Aifantis I,Martin C,Fehling HJ,Hoeflinger S,Leder P,von Boehmer H,Reizis Bdoi
10.1038/ni778keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
489-96issue
5eissn
1529-2908issn
1529-2916pii
ni778journal_volume
3pub_type
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