CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.

abstract：:High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA sensing in tumor cells after radiation is rather limited. Here we demonstrate that irradiated tumor cells hijack caspase 9 signaling to suppress intrinsic DNA sensi...

journal_title：Nature immunology

authors： Han C,Liu Z,Zhang Y,Shen A,Dong C,Zhang A,Moore C,Ren Z,Lu C,Cao X,Zhang CL,Qiao J,Fu YX

更新日期：2020-05-01 00:00:00

abstract：:CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the ...

journal_title：Nature immunology

authors： Utzschneider DT,Gabriel SS,Chisanga D,Gloury R,Gubser PM,Vasanthakumar A,Shi W,Kallies A

更新日期：2020-10-01 00:00:00

abstract：:Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. These cells share transcriptional regulators with memory precursor cells, including T cell-specific transcription factor 1 (TCF1), but it is unclear whether they adopt distinct pr...

journal_title：Nature immunology

authors： Yao C,Sun HW,Lacey NE,Ji Y,Moseman EA,Shih HY,Heuston EF,Kirby M,Anderson S,Cheng J,Khan O,Handon R,Reilley J,Fioravanti J,Hu J,Gossa S,Wherry EJ,Gattinoni L,McGavern DB,O'Shea JJ,Schwartzberg PL,Wu T

更新日期：2019-07-01 00:00:00

abstract：:Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...

journal_title：Nature immunology

authors： Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

更新日期：2012-10-01 00:00:00

abstract：:Stimulation of Toll-like receptors (TLRs) initiates potent innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by the TLR3 ligand double-stran...

journal_title：Nature immunology

authors： Meylan E,Burns K,Hofmann K,Blancheteau V,Martinon F,Kelliher M,Tschopp J

更新日期：2004-05-01 00:00:00

abstract：:Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different...

journal_title：Nature immunology

authors： Hahn M,Nicholson MJ,Pyrdol J,Wucherpfennig KW

更新日期：2005-05-01 00:00:00

abstract：:T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of ...

journal_title：Nature immunology

authors： Kallies A,Hawkins ED,Belz GT,Metcalf D,Hommel M,Corcoran LM,Hodgkin PD,Nutt SL

更新日期：2006-05-01 00:00:00

abstract：:Ingested antigens lead to the generation of effector T cells that secrete interleukin 4 (IL-4) rather than interferon-gamma (IFN-gamma) and are capable of influencing naive T cells in their immediate environment to do the same. Using chimeric mice generated by aggregation of two genotypically different embryos, we fou...

journal_title：Nature immunology

authors： Alpan O,Bachelder E,Isil E,Arnheiter H,Matzinger P

更新日期：2004-06-01 00:00:00

abstract：:Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...

journal_title：Nature immunology

authors： Karaghiosoff M,Steinborn R,Kovarik P,Kriegshäuser G,Baccarini M,Donabauer B,Reichart U,Kolbe T,Bogdan C,Leanderson T,Levy D,Decker T,Müller M

更新日期：2003-05-01 00:00:00

abstract：:Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition...

journal_title：Nature immunology

authors： Kidani Y,Elsaesser H,Hock MB,Vergnes L,Williams KJ,Argus JP,Marbois BN,Komisopoulou E,Wilson EB,Osborne TF,Graeber TG,Reue K,Brooks DG,Bensinger SJ

更新日期：2013-05-01 00:00:00

abstract：:Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...

journal_title：Nature immunology

authors： Abarrategui I,Krangel MS

更新日期：2006-10-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

journal_title：Nature immunology

authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

更新日期：2017-10-18 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution co...

journal_title：Nature immunology

authors： Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB,ImmGen Project Consortium.

更新日期：2013-01-01 00:00:00

abstract：:The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and c...

journal_title：Nature immunology

authors： Wyss L,Stadinski BD,King CG,Schallenberg S,McCarthy NI,Lee JY,Kretschmer K,Terracciano LM,Anderson G,Surh CD,Huseby ES,Palmer E

更新日期：2016-09-01 00:00:00

abstract：:Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonst...

journal_title：Nature immunology

authors： Li Z,Zhang Y,Liu Z,Wu X,Zheng Y,Tao Z,Mao K,Wang J,Lin G,Tian L,Ji Y,Qin M,Sun S,Zhu X,Sun B

更新日期：2011-02-01 00:00:00

abstract：:Interferon-γ (IFN-γ) is essential for the innate immune response to intracellular bacteria. Noncoding RNAs and RNA-binding proteins (RBPs) need to be further considered in studies of regulation of the IFN-γ-activated signaling pathway in macrophages. In the present study, we found that the microRNA miR-1 promoted IFN-...

journal_title：Nature immunology

authors： Xu H,Jiang Y,Xu X,Su X,Liu Y,Ma Y,Zhao Y,Shen Z,Huang B,Cao X

更新日期：2019-12-01 00:00:00

abstract：:Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of the chemokine receptor CXCRI was found to stimulate rapid formation of beta-arrestin complexes with Hck or c-Fgr. Formation o...

journal_title：Nature immunology

authors： Barlic J,Andrews JD,Kelvin AA,Bosinger SE,DeVries ME,Xu L,Dobransky T,Feldman RD,Ferguson SS,Kelvin DJ

更新日期：2000-09-01 00:00:00

abstract：:Autophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18. Here we show that the induction of AIM2 or NLRP3 inflammasomes in...

journal_title：Nature immunology

authors： Shi CS,Shenderov K,Huang NN,Kabat J,Abu-Asab M,Fitzgerald KA,Sher A,Kehrl JH

更新日期：2012-01-29 00:00:00

abstract：:CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses are not understood. We show here that T cell recognition of glucose monomycolate antigens with long (C(80)) alkyl chains involves the delivery of CD1b proteins an...

journal_title：Nature immunology

authors： Moody DB,Briken V,Cheng TY,Roura-Mir C,Guy MR,Geho DH,Tykocinski ML,Besra GS,Porcelli SA

更新日期：2002-05-01 00:00:00

abstract：:The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T(H)-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS...

journal_title：Nature immunology

authors： Zhang F,Meng G,Strober W

更新日期：2008-11-01 00:00:00

abstract：:Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell a...

journal_title：Nature immunology

authors： Miyazaki M,Miyazaki K,Chen S,Itoi M,Miller M,Lu LF,Varki N,Chang AN,Broide DH,Murre C

更新日期：2014-08-01 00:00:00

abstract：:Tim-3 is a T helper type 1 (T(H)1)-specific cell surface molecule that seems to regulate T(H)1 responses and the induction of peripheral tolerance. However, the identity of the Tim-3 ligand and the mechanism by which this ligand inhibits the function of effector T(H)1 cells remain unknown. Here we show that galectin-9...

journal_title：Nature immunology

authors： Zhu C,Anderson AC,Schubart A,Xiong H,Imitola J,Khoury SJ,Zheng XX,Strom TB,Kuchroo VK

更新日期：2005-12-01 00:00:00

abstract：:Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human c...

journal_title：Nature immunology

authors： Slevogt H,Zabel S,Opitz B,Hocke A,Eitel J,N'guessan PD,Lucka L,Riesbeck K,Zimmermann W,Zweigner J,Temmesfeld-Wollbrueck B,Suttorp N,Singer BB

更新日期：2008-11-01 00:00:00

abstract：:We define here the specificity and significance of proteases in the endoplasmic reticulum (ER) that generate peptides for presentation by major histocompatibility complex (MHC) class I molecules. We show that aminopeptidases efficiently trimmed all residues except proline that flank the NH2-termini of antigenic precur...

journal_title：Nature immunology

authors： Serwold T,Gaw S,Shastri N

更新日期：2001-07-01 00:00:00

abstract：:Immunological reactions are propelled by ever-changing signals that alter the translational ability of the RNA in the cells involved. Such alterations are considered to be consequential modifications in the transcriptomic decoding of the genetic blueprint. The identification of RNA-binding protein (RBP) assemblies eng...

journal_title：Nature immunology

authors： Kafasla P,Skliris A,Kontoyiannis DL

更新日期：2014-06-01 00:00:00

abstract：:The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...

journal_title：Nature immunology

authors： Stumhofer JS,Tait ED,Quinn WJ 3rd,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:In the version of this article initially published, some identification of the supplementary information was incorrect. The items originally called Supplementary Tables 1, 2, 3, 4 and 5 should be Source Data Figures 1, 2, 4, 5 and 7, respectively; those originally called Supplementary Tables 6, 7 and 8 should be Suppl...

journal_title：Nature immunology

authors： Zhang M,Dong Y,Hu F,Yang D,Zhao Q,Lv C,Wang Y,Xia C,Weng Q,Liu X,Li C,Zhou P,Wang T,Guan Y,Guo R,Liu L,Geng Y,Wu H,Du J,Hu Z,Xu S,Chen J,He A,Liu B,Wang D,Yang YG,Wang J

更新日期：2018-09-01 00:00:00

abstract：:Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of path...

journal_title：Nature immunology

authors： Banchereau J,Pascual V,O'Garra A

更新日期：2012-10-01 00:00:00

abstract：:Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill tissue-specific and niche-specific functions. These range from dedicated homeostatic functions, such as clearance of cellular debris and iron processing, to central roles in tissue immune surveillance, response to infection and the...

journal_title：Nature immunology

authors： Davies LC,Jenkins SJ,Allen JE,Taylor PR

更新日期：2013-10-01 00:00:00

abstract：:Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test whether loss of Nedd4 affects T cells in the same way, we generated Nedd4(+/+) and Nedd4(-/-) fetal l...

journal_title：Nature immunology

authors： Yang B,Gay DL,MacLeod MK,Cao X,Hala T,Sweezer EM,Kappler J,Marrack P,Oliver PM

更新日期：2008-12-01 00:00:00