Abstract:
:T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of terminal B cell differentiation, was expressed in a subset of antigen-experienced CD4(+) and CD8(+) T cells. Mice reconstituted with fetal liver stem cells expressing a mutant Blimp-1 lacking the DNA-binding domain developed a lethal multiorgan inflammatory disease caused by an accumulation of effector and memory T cells. These data identify Blimp-1 as an essential regulator of T cell homeostasis and suggest that Blimp-1 regulates both B cell and T cell differentiation.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Kallies A,Hawkins ED,Belz GT,Metcalf D,Hommel M,Corcoran LM,Hodgkin PD,Nutt SLdoi
10.1038/ni1321keywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
466-74issue
5eissn
1529-2908issn
1529-2916pii
ni1321journal_volume
7pub_type
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