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Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.

Abstract：

:By genetically ablating IkappaB kinase (IKK)-mediated activation of the transcription factor NF-kappaB in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin lambda-chain-positive B cells are generated in the absence of rearrangements in the locus encoding immunoglobulin kappa-chain, we define here two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappaB signaling. During the first phase, in which NF-kappaB signaling is dispensable, predominantly kappa-chain-positive B cells are generated, which undergo efficient receptor editing. In the second phase, predominantly lambda-chain-positive B cells are generated whose development is ontogenetically timed to occur after rearrangements of the locus encoding kappa-chain. This second phase of development is dependent on NF-kappaB signals, which can be substituted by transgenic expression of the prosurvival factor Bcl-2.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Derudder E,Cadera EJ,Vahl JC,Wang J,Fox CJ,Zha S,van Loo G,Pasparakis M,Schlissel MS,Schmidt-Supprian M,Rajewsky K

doi

10.1038/ni.1732

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

647-54

issue

6

eissn

1529-2908

issn

1529-2916

pii

ni.1732

journal_volume

10

pub_type

杂志文章

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