Abstract:
:Transcription factors of the NF-kappaB family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-kappaB activation is cytoplasmic and leads to the release of NF-kappaB proteins from IkappaB molecules, specific inhibitors that prevent their nuclear accumulation. However, it is becoming increasingly apparent that in addition to this required activation step, both recruitment of NF-kappaB to target genes and NF-kappaB-induced transcriptional events after recruitment are actively controlled. Regulated recruitment of NF-kappaB to chromatin generates kinetic complexity in NF-kappaB-dependent gene induction and 'wires' NF-kappaB-regulated gene activity to simultaneously activated pathways and transcription factors.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Natoli G,Saccani S,Bosisio D,Marazzi Idoi
10.1038/ni1196keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
439-45issue
5eissn
1529-2908issn
1529-2916pii
ni1196journal_volume
6pub_type
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更新日期:2014-03-01 00:00:00
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更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-05-01 00:00:00
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pub_type: 传,历史文章,杂志文章
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更新日期:2006-06-01 00:00:00
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更新日期:2002-11-01 00:00:00
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更新日期:2014-08-01 00:00:00
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journal_title:Nature immunology
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更新日期:2016-05-19 00:00:00
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更新日期:2007-07-01 00:00:00
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journal_title:Nature immunology
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
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