Abstract：
:Immune synapses form between T cells and antigen-presenting cells (APCs). Increasing evidence suggests synapses must form flexibly to accommodate ongoing motility and displacement of the synapse. Here, time-lapse total internal reflection fluorescence (TIRF) microscopy showed that signaling via the T cell antigen receptor (TCR) occurred during synapse translation. TCR microclusters in motile synapses did not flow directly into supramolecular activating complexes (SMACs) but were directed, independently of myosin II contractility, toward an F-actin-poor 'sink' region. Inward microcluster flow often followed collapse of the leading edge, which suggested that actin depolymerization regulated microcluster flow and the formation of SMACs. The coordination of TCR movement with the translocation of this 'sink' shows how T cells coordinate TCR signaling and microcluster flow in dynamic physiological synapses.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Beemiller P,Jacobelli J,Krummel MFdoi
10.1038/ni.2364subject
Has Abstractpub_date
2012-07-01 00:00:00pages
787-95issue
8eissn
1529-2908issn
1529-2916pii
ni.2364journal_volume
13pub_type
杂志文章abstract：:T lymphocytes and B lymphocytes integrate activating signals to control the size of their proliferative response. Here we report that such control was achieved by timed changes in the production rate of cell-cycle-regulating proto-oncoprotein Myc, with division cessation occurring when Myc levels fell below a critical...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3598
更新日期：2017-01-01 00:00:00
abstract：:Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylation, a protein post-transl...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3487
更新日期：2016-08-01 00:00:00
abstract：:By genetically ablating IkappaB kinase (IKK)-mediated activation of the transcription factor NF-kappaB in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin lambda-chain-positive B cells are generated in the absence of rearrangements in the locus encoding immunoglobulin kappa-chain, we define h...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1732
更新日期：2009-06-01 00:00:00
abstract：:The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influx in naive T lymphocytes is unknown. Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of na...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1793
更新日期：2009-12-01 00:00:00
abstract：:Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0250-8
更新日期：2019-01-01 00:00:00
abstract：:Cytosolic detection of pathogen-derived nucleic acids is critical for the initiation of innate immune defense against diverse bacterial, viral and eukaryotic pathogens. Conversely, inappropriate responses to cytosolic nucleic acids can produce severe autoimmune pathology. The host protein STING has been identified as ...
journal_title：Nature immunology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/79767
更新日期：2000-09-01 00:00:00
abstract：:Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional chemokine CXCL10. By extending those initial findings to pre-clinical mod...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0321-5
更新日期：2019-03-01 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1628
更新日期：2008-08-01 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/76877
更新日期：2000-07-01 00:00:00
abstract：:Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokin...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/90675
更新日期：2001-08-01 00:00:00
abstract：:In the version of this Research Highlight initially published, the url for the linked article was incorrect ( https://doi.org/10.1172/JCI90647JCI90647 ). The correct link is https://doi.org/10.1172/JCI90647 . The error has been corrected in the HTML and PDF versions of the article. ...
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pub_type： 杂志文章,已发布勘误
doi：10.1038/s41590-018-0159-2
更新日期：2018-08-01 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3324
更新日期：2016-01-01 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1053
更新日期：2004-04-01 00:00:00
abstract：:Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely how TCR signals are channeled toward specific targets remains unclear. TCR stimulation triggers 'alternative' activation of the mitogen-activated protein kinas...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1422
更新日期：2007-02-01 00:00:00
abstract：:Regions of the normal arterial intima predisposed to atherosclerosis are sites of ongoing monocyte trafficking and also contain resident myeloid cells with features of dendritic cells. However, the pathophysiological roles of these cells are poorly understood. Here we found that intimal myeloid cells underwent reverse...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3564
更新日期：2016-11-01 00:00:00
abstract：:The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-beta receptor I (TbetaRI) in T cells blocked the appearance of CD4+CD25+Foxp3+ thymocytes a...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1607
更新日期：2008-06-01 00:00:00
abstract：:Regenerative stem cell-like memory (TSCM) CD8+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing...
journal_title：Nature immunology
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doi：10.1038/s41590-020-00818-9
更新日期：2021-01-01 00:00:00
abstract：:Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous admi...
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pub_type： 杂志文章
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更新日期：2012-06-17 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
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更新日期：2010-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-11-06 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3706
更新日期：2017-05-01 00:00:00
abstract：:The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion w...
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pub_type： 杂志文章
doi：10.1038/ni1288
更新日期：2006-01-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/ni.3713. ...
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pub_type： 杂志文章,已发布勘误
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更新日期：2017-10-18 00:00:00
abstract：:In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...
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pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Nature immunology
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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doi：10.1038/ni965
更新日期：2003-09-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 评论,杂志文章
doi：10.1038/s41590-018-0240-x
更新日期：2018-11-01 00:00:00
