Abstract:
:The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion was prevented by specific deletion in the B cell compartment. We demonstrate that ERp57 was central for recruitment of MHC class I molecules into the loading complex. In ERp57-deficient cells, we found short-lived interaction of MHC class I molecules with the loading complex. Thus, in the steady state, very few MHC class I molecules were present in the loading complex. Surface H-2K(b)-peptide expression and stability were reduced, and presentation of a model antigen was decreased. Our results indicate that ERp57 does not influence the redox state of MHC class I molecules but is an essential structural component required for stable assembly of the peptide-loading complex.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Garbi N,Tanaka S,Momburg F,Hämmerling GJdoi
10.1038/ni1288keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
93-102issue
1eissn
1529-2908issn
1529-2916pii
ni1288journal_volume
7pub_type
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