Abstract:
:Effective clinical cancer immunotherapies, such as administration of the cytokine IL-2, adoptive cell transfer (ACT) and the recent success of blockade of the checkpoint modulators CTLA-4 and PD-1, have been developed without clear identification of the immunogenic targets expressed by human cancers in vivo. Immunotherapy of patients with cancer through the use of ACT with autologous lymphocytes has provided an opportunity to directly investigate the antigen recognition of lymphocytes that mediate cancer regression in humans. High-throughput immunological testing of such lymphocytes in combination with improvements in deep sequencing of the autologous cancer have provided new insight into the molecular characterization and incidence of anti-tumor lymphocytes present in patients with cancer. Here we highlight evidence suggesting that T cells that target tumor neoantigens arising from cancer mutations are the main mediators of many effective cancer immunotherapies in humans.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Tran E,Robbins PF,Rosenberg SAdoi
10.1038/ni.3682subject
Has Abstractpub_date
2017-02-15 00:00:00pages
255-262issue
3eissn
1529-2908issn
1529-2916pii
ni.3682journal_volume
18pub_type
杂志文章,评审abstract::Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell a...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2928
更新日期:2014-08-01 00:00:00
abstract::The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immun...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1475
更新日期:2007-06-01 00:00:00
abstract::The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), tha...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0698-1
更新日期:2020-07-01 00:00:00
abstract::The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, pr...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni907
更新日期:2003-04-01 00:00:00
abstract::STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs. Although STING ER exit is the rate-limiting step in STING signal...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0730-5
更新日期:2020-08-01 00:00:00
abstract::The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regula...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3791
更新日期:2017-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0545-4
更新日期:2019-12-01 00:00:00
abstract::Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1187
更新日期:2005-05-01 00:00:00
abstract::Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni817
更新日期:2002-08-01 00:00:00
abstract::Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentrations. Here we show that the conditional deletion o...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni892
更新日期:2003-03-01 00:00:00
abstract::According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, wi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3412
更新日期:2016-06-01 00:00:00
abstract::Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is essential in recruiting signaling molecules to the TNFR1 receptor complex. Interferon-gamma (IFN-gamma) is a potent activator of macrophages and uses signal transducer and activator of transcription 1-alpha (STAT1-alpha) for signal tra...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1025
更新日期:2004-02-01 00:00:00
abstract::Dendritic cells (DCs) initiate and regulate immunity against foreign and self antigens. Here we identified more than 200 individual major histocompatibility complex class II-associated peptides on human DCs and found that mature DCs selectively upregulated the self peptide CLIP. CLIP cosegregated together with foreign...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1108
更新日期:2004-09-01 00:00:00
abstract::In the version of this Research Highlight initially published, the url for the linked article was incorrect ( https://doi.org/10.1172/JCI90647JCI90647 ). The correct link is https://doi.org/10.1172/JCI90647 . The error has been corrected in the HTML and PDF versions of the article. ...
journal_title:Nature immunology
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41590-018-0159-2
更新日期:2018-08-01 00:00:00
abstract::In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2981
更新日期:2014-10-01 00:00:00
abstract::The present paradigm dictates that phagocytosis is accomplished mainly by 'professional' phagocytes (such as macrophages and monocytes), whereas B cells lack phagocytic capabilities. Here we demonstrate that B cells from teleost fish have potent in vitro and in vivo phagocytic activities. Particle uptake by B cells in...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1389
更新日期:2006-10-01 00:00:00
abstract::The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion w...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1288
更新日期:2006-01-01 00:00:00
abstract::The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is unclear. Here we found that the TCR repertoire of thymic T(reg) cells in TCRbeta-transgenic...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1318
更新日期:2006-04-01 00:00:00
abstract::High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory diseases. The molecular mechanisms of how HDL can modulate inflammation, p...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2784
更新日期:2014-02-01 00:00:00
abstract::The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1085
更新日期:2004-07-01 00:00:00
abstract::The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led to the so-called 'hygiene hypothesis'. Given the epidemiological evidence and rec...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3851
更新日期:2017-10-18 00:00:00
abstract::Interleukin 17 (IL-17)-producing T helper 17 cells (T(H)-17 cells) have been described as a T helper cell subset distinct from T helper type 1 (T(H)1) and T(H)2 cells, with specific functions in antimicrobial defense and autoimmunity. The factors driving human T(H)-17 differentiation remain controversial. Using a syst...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1613
更新日期:2008-06-01 00:00:00
abstract::Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni0901-842
更新日期:2001-09-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 评论,杂志文章
doi:10.1038/s41590-018-0240-x
更新日期:2018-11-01 00:00:00
abstract::NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies have suggested a positive regulatory role for NLRX1 in inducing antiv...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3853
更新日期:2017-12-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0476-0
更新日期:2019-10-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-020-00809-w
更新日期:2020-12-01 00:00:00
abstract::The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. ...
journal_title:Nature immunology
pub_type: 评论,新闻
doi:10.1038/ni.2042
更新日期:2011-06-01 00:00:00
abstract::Nonmuscle myosin light-chain kinase (MYLK) mediates increased lung vascular endothelial permeability in lipopolysaccharide-induced lung inflammatory injury, the chief cause of the acute respiratory distress syndrome. In a lung injury model, we demonstrate here that MYLK was also essential for neutrophil transmigration...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1628
更新日期:2008-08-01 00:00:00
abstract::The transcription factor BATF is required for the differentiation of interleukin 17 (IL-17)-producing helper T cells (TH17 cells) and follicular helper T cells (TFH cells). Here we identified a fundamental role for BATF in regulating the differentiation of effector of CD8(+) T cells. BATF-deficient CD8(+) T cells show...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2834
更新日期:2014-04-01 00:00:00