Abstract：
:According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, with the notable exception that both pathways are proposed to generate all myeloid innate immune cell types through the same myeloid-restricted pre-granulocyte-macrophage progenitor (pre-GM) (Lin(-)Sca-1(-)c-Kit(+)CD41(-)FcγRII/III(-)CD150(-)CD105(-)). By single-cell transcriptome profiling of pre-GMs, we identified distinct myeloid differentiation pathways: a pathway expressing the gene encoding the transcription factor GATA-1 generated mast cells, eosinophils, megakaryocytes and erythroid cells, and a pathway lacking expression of that gene generated monocytes, neutrophils and lymphocytes. These results identify an early hematopoietic-lineage bifurcation that separates the myeloid lineages before their segregation from other hematopoietic-lineage potential.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Drissen R,Buza-Vidas N,Woll P,Thongjuea S,Gambardella A,Giustacchini A,Mancini E,Zriwil A,Lutteropp M,Grover A,Mead A,Sitnicka E,Jacobsen SEW,Nerlov Cdoi
10.1038/ni.3412subject
Has Abstractpub_date
2016-06-01 00:00:00pages
666-676issue
6eissn
1529-2908issn
1529-2916journal_volume
17pub_type
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