Abstract:
:The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexity has been widely disseminated. Here we present data showing that the generation of the restricted TCR variable gamma-region gene repertoire of intestinal intraepithelial lymphocytes was regulated by interleukin 15, which induced local chromatin modifications specific for the variable gamma-region gene segment and enhanced accessibility conducive to subsequent targeted gene rearrangement. This cytokine-directed tissue-specific TCR repertoire formation probably reflects distinct TCR repertoire selection criteria for gammadelta and alphabeta T cell lineages adopted for different antigen-recognition strategies.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Zhao H,Nguyen H,Kang Jdoi
10.1038/ni1267keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1263-71issue
12eissn
1529-2908issn
1529-2916pii
ni1267journal_volume
6pub_type
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