Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment.

abstract：:The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxi...

journal_title：Nature immunology

authors： Yuk JM,Shin DM,Lee HM,Kim JJ,Kim SW,Jin HS,Yang CS,Park KA,Chanda D,Kim DK,Huang SM,Lee SK,Lee CH,Kim JM,Song CH,Lee SY,Hur GM,Moore DD,Choi HS,Jo EK

更新日期：2011-07-03 00:00:00

abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-re...

journal_title：Nature immunology

authors： Weizman OE,Song E,Adams NM,Hildreth AD,Riggan L,Krishna C,Aguilar OA,Leslie CS,Carlyle JR,Sun JC,O'Sullivan TE

更新日期：2019-08-01 00:00:00

abstract：:CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral inter...

journal_title：Nature immunology

authors： Yewdell JW,Hill AB

更新日期：2002-11-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of α-smooth muscle actin (α-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells ...

journal_title：Nature immunology

authors： Ludin A,Itkin T,Gur-Cohen S,Mildner A,Shezen E,Golan K,Kollet O,Kalinkovich A,Porat Z,D'Uva G,Schajnovitz A,Voronov E,Brenner DA,Apte RN,Jung S,Lapidot T

更新日期：2012-11-01 00:00:00

abstract：:Immunological reactions are propelled by ever-changing signals that alter the translational ability of the RNA in the cells involved. Such alterations are considered to be consequential modifications in the transcriptomic decoding of the genetic blueprint. The identification of RNA-binding protein (RBP) assemblies eng...

journal_title：Nature immunology

authors： Kafasla P,Skliris A,Kontoyiannis DL

更新日期：2014-06-01 00:00:00

abstract：:Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes, exposing the metabolic and protein synthesis machiner...

journal_title：Nature immunology

authors： Howden AJM,Hukelmann JL,Brenes A,Spinelli L,Sinclair LV,Lamond AI,Cantrell DA

更新日期：2019-11-01 00:00:00

abstract：:The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015. ...

journal_title：Nature immunology

authors： Walker LS,Ziegler S,Becher B

更新日期：2016-03-01 00:00:00

abstract：:Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was ...

journal_title：Nature immunology

authors： A-Gonzalez N,Guillen JA,Gallardo G,Diaz M,de la Rosa JV,Hernandez IH,Casanova-Acebes M,Lopez F,Tabraue C,Beceiro S,Hong C,Lara PC,Andujar M,Arai S,Miyazaki T,Li S,Corbi AL,Tontonoz P,Hidalgo A,Castrillo A

更新日期：2013-08-01 00:00:00

abstract：:The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. ...

journal_title：Nature immunology

authors： Ellyard JI,Vinuesa CG

更新日期：2011-06-01 00:00:00

abstract：:Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill tissue-specific and niche-specific functions. These range from dedicated homeostatic functions, such as clearance of cellular debris and iron processing, to central roles in tissue immune surveillance, response to infection and the...

journal_title：Nature immunology

authors： Davies LC,Jenkins SJ,Allen JE,Taylor PR

更新日期：2013-10-01 00:00:00

abstract：:STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs. Although STING ER exit is the rate-limiting step in STING signal...

journal_title：Nature immunology

authors： Zhang BC,Nandakumar R,Reinert LS,Huang J,Laustsen A,Gao ZL,Sun CL,Jensen SB,Troldborg A,Assil S,Berthelsen MF,Scavenius C,Zhang Y,Windross SJ,Olagnier D,Prabakaran T,Bodda C,Narita R,Cai Y,Zhang CG,Stenmark H,Do

更新日期：2020-08-01 00:00:00

abstract：:The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...

journal_title：Nature immunology

authors： Stumhofer JS,Tait ED,Quinn WJ 3rd,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Tanaka S,Ise W,Inoue T,Ito A,Ono C,Shima Y,Sakakibara S,Nakayama M,Fujii K,Miura I,Sharif J,Koseki H,Koni PA,Raman I,Li QZ,Kubo M,Fujiki K,Nakato R,Shirahige K,Araki H,Miura F,Ito T,Kawakami E,Baba Y,Kuros

更新日期：2020-12-01 00:00:00

abstract：:High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell-dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4-reporter system, we show here that CD4(+) foll...

journal_title：Nature immunology

authors： Reinhardt RL,Liang HE,Locksley RM

更新日期：2009-04-01 00:00:00

abstract：:Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B(-/-) mice had an increased number of peritoneal B1 cells. Splenic PIR-B(-/-) B2 cells were constitutively activated and proliferated much more than th...

journal_title：Nature immunology

authors： Ujike A,Takeda K,Nakamura A,Ebihara S,Akiyama K,Takai T

更新日期：2002-06-01 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic factor that...

journal_title：Nature immunology

authors： Beyaz S,Kim JH,Pinello L,Xifaras ME,Hu Y,Huang J,Kerenyi MA,Das PP,Barnitz RA,Herault A,Dogum R,Haining WN,Yilmaz ÖH,Passegue E,Yuan GC,Orkin SH,Winau F

更新日期：2017-02-01 00:00:00

abstract：:High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...

journal_title：Nature immunology

authors： Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP

更新日期：2011-05-01 00:00:00

abstract：:It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and pro...

journal_title：Nature immunology

authors： Migueles SA,Laborico AC,Shupert WL,Sabbaghian MS,Rabin R,Hallahan CW,Van Baarle D,Kostense S,Miedema F,McLaughlin M,Ehler L,Metcalf J,Liu S,Connors M

更新日期：2002-11-01 00:00:00

abstract：:Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monoc...

journal_title：Nature immunology

authors： Aegerter H,Kulikauskaite J,Crotta S,Patel H,Kelly G,Hessel EM,Mack M,Beinke S,Wack A

更新日期：2020-02-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2018-07-01 00:00:00

abstract：:T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is dynamically regulated to shape transcriptional responses to TCR signaling. We found that th...

journal_title：Nature immunology

authors： Roychoudhuri R,Clever D,Li P,Wakabayashi Y,Quinn KM,Klebanoff CA,Ji Y,Sukumar M,Eil RL,Yu Z,Spolski R,Palmer DC,Pan JH,Patel SJ,Macallan DC,Fabozzi G,Shih HY,Kanno Y,Muto A,Zhu J,Gattinoni L,O'Shea JJ,Okkenhau

更新日期：2016-07-01 00:00:00

abstract：:Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-6...

journal_title：Nature immunology

authors： Köhler F,Storch B,Kulathu Y,Herzog S,Kuppig S,Reth M,Jumaa H

更新日期：2005-02-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) develop from progenitor thymocytes after the engagement of T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular mechanisms are still unclear. Here we show that the Nr4a nuclear receptors, which are encoded by immediate-early genes upregulated by TCR...

journal_title：Nature immunology

authors： Sekiya T,Kashiwagi I,Yoshida R,Fukaya T,Morita R,Kimura A,Ichinose H,Metzger D,Chambon P,Yoshimura A

更新日期：2013-03-01 00:00:00

abstract：:In the version of this article initially published, the label (CASP4-C285A-HA) above the second and fifth lanes in the right blot in Fig. 1e is incorrect; the correct label is CASP4-C258A-HA. Also, the two labels at right above the plot in Fig. 6c were switched; the far right label should be 'Co-housed Serpinb1a-/-' (...

journal_title：Nature immunology

authors： Choi YJ,Kim S,Choi Y,Nielsen TB,Yan J,Lu A,Ruan J,Lee HR,Wu H,Spellberg B,Jung JU

更新日期：2019-05-01 00:00:00

abstract：:Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific o...

journal_title：Nature immunology

authors： Netea MG,Balkwill F,Chonchol M,Cominelli F,Donath MY,Giamarellos-Bourboulis EJ,Golenbock D,Gresnigt MS,Heneka MT,Hoffman HM,Hotchkiss R,Joosten LAB,Kastner DL,Korte M,Latz E,Libby P,Mandrup-Poulsen T,Mantovani A,Mills

更新日期：2017-07-19 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4 (IL-4) early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we have defined three subsets of i...

journal_title：Nature immunology

authors： Lee YJ,Holzapfel KL,Zhu J,Jameson SC,Hogquist KA

更新日期：2013-11-01 00:00:00

abstract：:The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor ty...

journal_title：Nature immunology

authors： Grigorova IL,Schwab SR,Phan TG,Pham TH,Okada T,Cyster JG

更新日期：2009-01-01 00:00:00

abstract：:The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system-related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression. Here we found that FBXL19, an 'orphan' member of the Skp1-Cullin-F-box family of...

journal_title：Nature immunology

authors： Zhao J,Wei J,Mialki RK,Mallampalli DF,Chen BB,Coon T,Zou C,Mallampalli RK,Zhao Y

更新日期：2012-06-03 00:00:00

abstract：:Although master transcription factors (TFs) are key to the development of specific T cell subsets, whether additional transcriptional regulators are induced by the same stimuli that dominantly repress the development of other, non-specific T cell lineages has not been fully elucidated. Through the use of regulatory T ...

journal_title：Nature immunology

authors： Wu C,Chen Z,Dardalhon V,Xiao S,Thalhamer T,Liao M,Madi A,Franca RF,Han T,Oukka M,Kuchroo V

更新日期：2017-03-01 00:00:00

abstract：:Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is essential in recruiting signaling molecules to the TNFR1 receptor complex. Interferon-gamma (IFN-gamma) is a potent activator of macrophages and uses signal transducer and activator of transcription 1-alpha (STAT1-alpha) for signal tra...

journal_title：Nature immunology

authors： Wesemann DR,Qin H,Kokorina N,Benveniste EN

更新日期：2004-02-01 00:00:00