The cytotoxic T cell proteome and its shaping by the kinase mTOR.

abstract：:The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of m...

journal_title：Nature immunology

authors： Zhu C,Chen W,Lou J,Rittase W,Li K

更新日期：2019-10-01 00:00:00

abstract：:Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...

journal_title：Nature immunology

authors： Biswas SK,Mantovani A

更新日期：2010-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Feigal EG,DeWitt ND,Cantilena C,Peck C,Stroncek D

更新日期：2019-10-01 00:00:00

abstract：:T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects....

journal_title：Nature immunology

authors： Ishimaru N,Kishimoto H,Hayashi Y,Sprent J

更新日期：2006-07-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2018-07-01 00:00:00

abstract：:Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...

journal_title：Nature immunology

authors： Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

更新日期：2012-10-01 00:00:00

abstract：:Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell receptor internalizat...

journal_title：Nature immunology

authors： Gomez TS,Hamann MJ,McCarney S,Savoy DN,Lubking CM,Heldebrant MP,Labno CM,McKean DJ,McNiven MA,Burkhardt JK,Billadeau DD

更新日期：2005-03-01 00:00:00

abstract：:The present paradigm dictates that phagocytosis is accomplished mainly by 'professional' phagocytes (such as macrophages and monocytes), whereas B cells lack phagocytic capabilities. Here we demonstrate that B cells from teleost fish have potent in vitro and in vivo phagocytic activities. Particle uptake by B cells in...

journal_title：Nature immunology

authors： Li J,Barreda DR,Zhang YA,Boshra H,Gelman AE,Lapatra S,Tort L,Sunyer JO

更新日期：2006-10-01 00:00:00

abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...

journal_title：Nature immunology

authors： Katerndahl CDS,Heltemes-Harris LM,Willette MJL,Henzler CM,Frietze S,Yang R,Schjerven H,Silverstein KAT,Ramsey LB,Hubbard G,Wells AD,Kuiper RP,Scheijen B,van Leeuwen FN,Müschen M,Kornblau SM,Farrar MA

更新日期：2017-06-01 00:00:00

abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

journal_title：Nature immunology

authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

更新日期：2005-08-01 00:00:00

abstract：:The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is unclear. Here we found that the TCR repertoire of thymic T(reg) cells in TCRbeta-transgenic...

journal_title：Nature immunology

authors： Hsieh CS,Zheng Y,Liang Y,Fontenot JD,Rudensky AY

更新日期：2006-04-01 00:00:00

abstract：:The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T(H)-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS...

journal_title：Nature immunology

authors： Zhang F,Meng G,Strober W

更新日期：2008-11-01 00:00:00

abstract：:High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...

journal_title：Nature immunology

authors： Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP

更新日期：2011-05-01 00:00:00

abstract：:Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs are exceptional amo...

journal_title：Nature immunology

authors： Weisel FJ,Mullett SJ,Elsner RA,Menk AV,Trivedi N,Luo W,Wikenheiser D,Hawse WF,Chikina M,Smita S,Conter LJ,Joachim SM,Wendell SG,Jurczak MJ,Winkler TH,Delgoffe GM,Shlomchik MJ

更新日期：2020-03-01 00:00:00

abstract：:CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release-activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combined immunodeficiency disease in humans. Here we generated CRACM1-deficient mice in which beta-galactosidase activity 'reporte...

journal_title：Nature immunology

authors： Vig M,DeHaven WI,Bird GS,Billingsley JM,Wang H,Rao PE,Hutchings AB,Jouvin MH,Putney JW,Kinet JP

更新日期：2008-01-01 00:00:00

abstract：:Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate t...

journal_title：Nature immunology

authors： Lau CM,Adams NM,Geary CD,Weizman OE,Rapp M,Pritykin Y,Leslie CS,Sun JC

更新日期：2018-09-01 00:00:00

abstract：:Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to i...

journal_title：Nature immunology

authors： Aaby P,Kollmann TR,Benn CS

更新日期：2014-10-01 00:00:00

abstract：:We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...

journal_title：Nature immunology

authors： Kotenko SV,Gallagher G,Baurin VV,Lewis-Antes A,Shen M,Shah NK,Langer JA,Sheikh F,Dickensheets H,Donnelly RP

更新日期：2003-01-01 00:00:00

abstract：:Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible regulatory T cells (iT(reg) cells). In vitro, Ndfip1-deficient T cells expressed normal amounts of the transcription factor Foxp3 during the first 48 h of iT(reg) cell d...

journal_title：Nature immunology

authors： Beal AM,Ramos-Hernández N,Riling CR,Nowelsky EA,Oliver PM

更新日期：2011-11-13 00:00:00

abstract：:TBK1 is essential for interferon-β (IFN-β) production and innate antiviral immunity. Here we identified the T cell anergy-related E3 ubiquitin ligase RNF128 as a positive regulator of TBK1 activation. RNF128 directly interacted with TBK1 through its protease-associated (PA) domain and catalyzed the K63-linked polyubiq...

journal_title：Nature immunology

authors： Song G,Liu B,Li Z,Wu H,Wang P,Zhao K,Jiang G,Zhang L,Gao C

更新日期：2016-12-01 00:00:00

abstract：:Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized. We show here that Fas kills activated primary T cells efficiently in the absence of active ...

journal_title：Nature immunology

authors： Holler N,Zaru R,Micheau O,Thome M,Attinger A,Valitutti S,Bodmer JL,Schneider P,Seed B,Tschopp J

更新日期：2000-12-01 00:00:00

abstract：:Toll-like receptor (TLR) signaling activates the inhibitor of transcription factor NF-κB (IκB) kinase (IKK) complex, which governs NF-κB-mediated transcription during inflammation. The RNase regnase-1 serves a critical role in preventing autoimmunity by controlling the stability of mRNAs that encode cytokines. Here we...

journal_title：Nature immunology

authors： Iwasaki H,Takeuchi O,Teraguchi S,Matsushita K,Uehata T,Kuniyoshi K,Satoh T,Saitoh T,Matsushita M,Standley DM,Akira S

更新日期：2011-10-30 00:00:00

abstract：:Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific o...

journal_title：Nature immunology

authors： Netea MG,Balkwill F,Chonchol M,Cominelli F,Donath MY,Giamarellos-Bourboulis EJ,Golenbock D,Gresnigt MS,Heneka MT,Hoffman HM,Hotchkiss R,Joosten LAB,Kastner DL,Korte M,Latz E,Libby P,Mandrup-Poulsen T,Mantovani A,Mills

更新日期：2017-07-19 00:00:00

abstract：:B cells are activated by two temporally distinct signals, the first provided by the binding of antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells. Here we found that B cells responded to antigen by rapidly increasing their metabolic activity, including both oxidative phosphorylatio...

journal_title：Nature immunology

authors： Akkaya M,Traba J,Roesler AS,Miozzo P,Akkaya B,Theall BP,Sohn H,Pena M,Smelkinson M,Kabat J,Dahlstrom E,Dorward DW,Skinner J,Sack MN,Pierce SK

更新日期：2018-08-01 00:00:00

abstract：:Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for...

journal_title：Nature immunology

authors： Parravicini V,Gadina M,Kovarova M,Odom S,Gonzalez-Espinosa C,Furumoto Y,Saitoh S,Samelson LE,O'Shea JJ,Rivera J

更新日期：2002-08-01 00:00:00

abstract：:Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monoc...

journal_title：Nature immunology

authors： Aegerter H,Kulikauskaite J,Crotta S,Patel H,Kelly G,Hessel EM,Mack M,Beinke S,Wack A

更新日期：2020-02-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Park JY,Park JH

更新日期：2018-11-01 00:00:00

abstract：:Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription fact...

journal_title：Nature immunology

authors： Gioulbasani M,Galaras A,Grammenoudi S,Moulos P,Dent AL,Sigvardsson M,Hatzis P,Kee BL,Verykokakis M

更新日期：2020-09-01 00:00:00

abstract：:The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were ess...

journal_title：Nature immunology

authors： Heink S,Yogev N,Garbers C,Herwerth M,Aly L,Gasperi C,Husterer V,Croxford AL,Möller-Hackbarth K,Bartsch HS,Sotlar K,Krebs S,Regen T,Blum H,Hemmer B,Misgeld T,Wunderlich TF,Hidalgo J,Oukka M,Rose-John S,Schmidt-Supp

更新日期：2017-01-01 00:00:00

abstract：:FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained unclear. Here, chromatin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci over- or under-...

journal_title：Nature immunology

authors： Kwon HK,Chen HM,Mathis D,Benoist C

更新日期：2017-11-01 00:00:00