Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

abstract：:The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the inte...

journal_title：Nature immunology

authors： Vacchio MS,Wang L,Bouladoux N,Carpenter AC,Xiong Y,Williams LC,Wohlfert E,Song KD,Belkaid Y,Love PE,Bosselut R

更新日期：2014-10-01 00:00:00

abstract：:Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is essential in recruiting signaling molecules to the TNFR1 receptor complex. Interferon-gamma (IFN-gamma) is a potent activator of macrophages and uses signal transducer and activator of transcription 1-alpha (STAT1-alpha) for signal tra...

journal_title：Nature immunology

authors： Wesemann DR,Qin H,Kokorina N,Benveniste EN

更新日期：2004-02-01 00:00:00

abstract：:DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...

journal_title：Nature immunology

authors： Hamerman JA,Tchao NK,Lowell CA,Lanier LL

更新日期：2005-06-01 00:00:00

abstract：:Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-6...

journal_title：Nature immunology

authors： Köhler F,Storch B,Kulathu Y,Herzog S,Kuppig S,Reth M,Jumaa H

更新日期：2005-02-01 00:00:00

abstract：:Mast cell activation induced by aggregation of Fc epsilon RI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways...

journal_title：Nature immunology

authors： Tam SY,Tsai M,Snouwaert JN,Kalesnikoff J,Scherrer D,Nakae S,Chatterjea D,Bouley DM,Galli SJ

更新日期：2004-08-01 00:00:00

abstract：:Using a human CD25 reporter transgene controlled by regulatory sequences from the gene encoding pre-T cell receptor alpha, we identified a common lymphocyte precursor (CLP-2) population that, in contrast to the previously identified CLP-1 population, was c-Kit-B220+. In short-term culture, the CLP-2 could be derived f...

journal_title：Nature immunology

authors： Martin CH,Aifantis I,Scimone ML,von Andrian UH,Reizis B,von Boehmer H,Gounari F

更新日期：2003-09-01 00:00:00

abstract：:The family of mammalian Nod-like receptors (NLRs) consists of critical intracellular immune proteins structurally related to plant resistance proteins. The NLRs NALP3 and IPAF, for example, can each form a multiprotein proinflammatory complex called the 'inflammasome', and mutations in the gene encoding Nod2, another ...

journal_title：Nature immunology

authors： Mayor A,Martinon F,De Smedt T,Pétrilli V,Tschopp J

更新日期：2007-05-01 00:00:00

abstract：:Mutational spectra analysis of 15 immunoglobulin genes suggested that consensus motifs RGYW and WA were universal descriptors of somatic hypermutation. Highly mutable sites, "hotspots", that matched WA were preferentially found in one DNA strand and RGYW hotspots were found in both strands. Analysis of base-substituti...

journal_title：Nature immunology

authors： Rogozin IB,Pavlov YI,Bebenek K,Matsuda T,Kunkel TA

更新日期：2001-06-01 00:00:00

abstract：:T lymphocytes and B lymphocytes integrate activating signals to control the size of their proliferative response. Here we report that such control was achieved by timed changes in the production rate of cell-cycle-regulating proto-oncoprotein Myc, with division cessation occurring when Myc levels fell below a critical...

journal_title：Nature immunology

authors： Heinzel S,Binh Giang T,Kan A,Marchingo JM,Lye BK,Corcoran LM,Hodgkin PD

更新日期：2017-01-01 00:00:00

abstract：:The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this di...

journal_title：Nature immunology

authors： Colucci F,Di Santo JP,Leibson PJ

更新日期：2002-09-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Dijkgraaf FE,Matos TR,Hoogenboezem M,Toebes M,Vredevoogd DW,Mertz M,van den Broek B,Song JY,Teunissen MBM,Luiten RM,Beltman JB,Schumacher TN

更新日期：2020-06-01 00:00:00

abstract：:Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice...

journal_title：Nature immunology

authors： Mohrs M,Blankespoor CM,Wang ZE,Loots GG,Afzal V,Hadeiba H,Shinkai K,Rubin EM,Locksley RM

更新日期：2001-09-01 00:00:00

abstract：:Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...

journal_title：Nature immunology

authors： Dogan I,Bertocci B,Vilmont V,Delbos F,Mégret J,Storck S,Reynaud CA,Weill JC

更新日期：2009-12-01 00:00:00

abstract：:Using both 'reverse genetics' and structural analysis, we have examined the in vivo relationship between antigenicity and T cell receptor (TCR) repertoire diversity. Influenza A virus infection of C57BL/6 mice induces profoundly different TCR repertoires specific for the nucleoprotein peptide of amino acids 366-374 (N...

journal_title：Nature immunology

authors： Turner SJ,Kedzierska K,Komodromou H,La Gruta NL,Dunstone MA,Webb AI,Webby R,Walden H,Xie W,McCluskey J,Purcell AW,Rossjohn J,Doherty PC

更新日期：2005-04-01 00:00:00

abstract：:The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, pr...

journal_title：Nature immunology

authors： Iwakoshi NN,Lee AH,Vallabhajosyula P,Otipoby KL,Rajewsky K,Glimcher LH

更新日期：2003-04-01 00:00:00

abstract：:Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) in lymphocytes triggers the release of Ca2+ from intracellular stores; this release of Ca2+ results in the opening of store-operated Ca2+ channels in the plasma membrane. Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb)...

journal_title：Nature immunology

authors： Miller AT,Sandberg M,Huang YH,Young M,Sutton S,Sauer K,Cooke MP

更新日期：2007-05-01 00:00:00

abstract：:Tyrosine phosphorylation of the adhesion molecule VE-cadherin is assumed to affect endothelial junction integrity. However, it remains unclear whether tyrosine residues of VE-cadherin are required for the induction of vascular permeability and the regulation of leukocyte extravasation in vivo. We found here that knock...

journal_title：Nature immunology

authors： Wessel F,Winderlich M,Holm M,Frye M,Rivera-Galdos R,Vockel M,Linnepe R,Ipe U,Stadtmann A,Zarbock A,Nottebaum AF,Vestweber D

更新日期：2014-03-01 00:00:00

abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

journal_title：Nature immunology

authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

更新日期：2005-08-01 00:00:00

abstract：:The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-kappaB; however, little is known about the mechanisms of A20-mediated inactivation of signaling intermediates such as RIP1. Here we demonstrate that the regulatory molecule ...

journal_title：Nature immunology

authors： Shembade N,Harhaj NS,Parvatiyar K,Copeland NG,Jenkins NA,Matesic LE,Harhaj EW

更新日期：2008-03-01 00:00:00

abstract：:As a result of decades of research-driven breakthroughs in basic and clinical science and recent advances in the broad-scale implementation of interventions for the prevention and treatment of infection with HIV, a turning point has been reached in the global HIV-AIDS pandemic. To end the pandemic and achieve the goal...

journal_title：Nature immunology

authors： Fauci AS,Folkers GK,Dieffenbach CW

更新日期：2013-11-01 00:00:00

abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

journal_title：Nature immunology

authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

更新日期：2004-01-01 00:00:00

abstract：:Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous admi...

journal_title：Nature immunology

authors： Kanaya T,Hase K,Takahashi D,Fukuda S,Hoshino K,Sasaki I,Hemmi H,Knoop KA,Kumar N,Sato M,Katsuno T,Yokosuka O,Toyooka K,Nakai K,Sakamoto A,Kitahara Y,Jinnohara T,McSorley SJ,Kaisho T,Williams IR,Ohno H

更新日期：2012-06-17 00:00:00

abstract：:Toll-like receptor (TLR) signaling activates the inhibitor of transcription factor NF-κB (IκB) kinase (IKK) complex, which governs NF-κB-mediated transcription during inflammation. The RNase regnase-1 serves a critical role in preventing autoimmunity by controlling the stability of mRNAs that encode cytokines. Here we...

journal_title：Nature immunology

authors： Iwasaki H,Takeuchi O,Teraguchi S,Matsushita K,Uehata T,Kuniyoshi K,Satoh T,Saitoh T,Matsushita M,Standley DM,Akira S

更新日期：2011-10-30 00:00:00

abstract：:Stimulation of Toll-like receptors (TLRs) initiates potent innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by the TLR3 ligand double-stran...

journal_title：Nature immunology

authors： Meylan E,Burns K,Hofmann K,Blancheteau V,Martinon F,Kelliher M,Tschopp J

更新日期：2004-05-01 00:00:00

abstract：:CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane. CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD). Here we investigated the role of CARMA1 in T cell act...

journal_title：Nature immunology

authors： Gaide O,Favier B,Legler DF,Bonnet D,Brissoni B,Valitutti S,Bron C,Tschopp J,Thome M

更新日期：2002-09-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Soveg F,von Moltke J,Savan R

更新日期：2019-02-01 00:00:00

abstract：:The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hyperm...

journal_title：Nature immunology

authors： Manis JP,Morales JC,Xia Z,Kutok JL,Alt FW,Carpenter PB

更新日期：2004-05-01 00:00:00

abstract：:Although much is known about the migration of T cells from blood to lymph nodes, less is known about the mechanisms regulating the migration of T cells from tissues into lymph nodes through afferent lymphatics. Here we investigated T cell egress from nonlymphoid tissues into afferent lymph in vivo and developed an exp...

journal_title：Nature immunology

authors： Ledgerwood LG,Lal G,Zhang N,Garin A,Esses SJ,Ginhoux F,Merad M,Peche H,Lira SA,Ding Y,Yang Y,He X,Schuchman EH,Allende ML,Ochando JC,Bromberg JS

更新日期：2008-01-01 00:00:00

abstract：:CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...

journal_title：Nature immunology

authors： Cai G,Anumanthan A,Brown JA,Greenfield EA,Zhu B,Freeman GJ

更新日期：2008-02-01 00:00:00

abstract：:Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...

journal_title：Nature immunology

authors： Karaghiosoff M,Steinborn R,Kovarik P,Kriegshäuser G,Baccarini M,Donabauer B,Reichart U,Kolbe T,Bogdan C,Leanderson T,Levy D,Decker T,Müller M

更新日期：2003-05-01 00:00:00