A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells.

abstract：:Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human c...

journal_title：Nature immunology

authors： Slevogt H,Zabel S,Opitz B,Hocke A,Eitel J,N'guessan PD,Lucka L,Riesbeck K,Zimmermann W,Zweigner J,Temmesfeld-Wollbrueck B,Suttorp N,Singer BB

更新日期：2008-11-01 00:00:00

abstract：:We have identified a silencer and an antisilencing element that interact at a distance of 85 kilobases to regulate expression of the recombination activating genes Rag1 and Rag2 in thymocytes. Transgenic experiments showed that Rag promoter-proximal cis elements directed tissue-specific expression and that a Runx-depe...

journal_title：Nature immunology

authors： Yannoutsos N,Barreto V,Misulovin Z,Gazumyan A,Yu W,Rajewsky N,Peixoto BR,Eisenreich T,Nussenzweig MC

更新日期：2004-04-01 00:00:00

abstract：:After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...

journal_title：Nature immunology

authors： Henrickson SE,Mempel TR,Mazo IB,Liu B,Artyomov MN,Zheng H,Peixoto A,Flynn MP,Senman B,Junt T,Wong HC,Chakraborty AK,von Andrian UH

更新日期：2008-03-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

journal_title：Nature immunology

authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

更新日期：2017-10-18 00:00:00

abstract：:Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokin...

journal_title：Nature immunology

authors： Tripp RA,Jones LP,Haynes LM,Zheng H,Murphy PM,Anderson LJ

更新日期：2001-08-01 00:00:00

abstract：:Ingested antigens lead to the generation of effector T cells that secrete interleukin 4 (IL-4) rather than interferon-gamma (IFN-gamma) and are capable of influencing naive T cells in their immediate environment to do the same. Using chimeric mice generated by aggregation of two genotypically different embryos, we fou...

journal_title：Nature immunology

authors： Alpan O,Bachelder E,Isil E,Arnheiter H,Matzinger P

更新日期：2004-06-01 00:00:00

abstract：:In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article. ...

journal_title：Nature immunology

authors： Zemmour D,Zilionis R,Kiner E,Klein AM,Mathis D,Benoist C

更新日期：2018-06-01 00:00:00

abstract：:Mast cell activation induced by aggregation of Fc epsilon RI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways...

journal_title：Nature immunology

authors： Tam SY,Tsai M,Snouwaert JN,Kalesnikoff J,Scherrer D,Nakae S,Chatterjea D,Bouley DM,Galli SJ

更新日期：2004-08-01 00:00:00

abstract：:Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish ...

journal_title：Nature immunology

authors： Sakaguchi S

更新日期：2005-04-01 00:00:00

abstract：:Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...

journal_title：Nature immunology

authors： Biswas SK,Mantovani A

更新日期：2010-10-01 00:00:00

abstract：:Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β. One therapy for type 2 diabetes, g...

journal_title：Nature immunology

authors： Masters SL,Dunne A,Subramanian SL,Hull RL,Tannahill GM,Sharp FA,Becker C,Franchi L,Yoshihara E,Chen Z,Mullooly N,Mielke LA,Harris J,Coll RC,Mills KH,Mok KH,Newsholme P,Nuñez G,Yodoi J,Kahn SE,Lavelle EC,O'Neill

更新日期：2010-10-01 00:00:00

abstract：:The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell b...

journal_title：Nature immunology

authors： Dustin ML,Cooper JA

更新日期：2000-07-01 00:00:00

abstract：:DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...

journal_title：Nature immunology

authors： Hamerman JA,Tchao NK,Lowell CA,Lanier LL

更新日期：2005-06-01 00:00:00

abstract：:The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...

journal_title：Nature immunology

authors： Stumhofer JS,Tait ED,Quinn WJ 3rd,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

journal_title：Nature immunology

authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

更新日期：2001-03-01 00:00:00

abstract：:In the version of this Research Highlight initially published, the url for the linked article was incorrect ( https://doi.org/10.1172/JCI90647JCI90647 ). The correct link is https://doi.org/10.1172/JCI90647 . The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature immunology

authors： Fehervari Z

更新日期：2018-08-01 00:00:00

abstract：:Cooperation between different innate signaling pathways induced by pattern-recognition receptors (PRRs) on dendritic cells (DCs) is crucial for tailoring adaptive immunity to pathogens. Here we show that carbohydrate-specific signaling through the C-type lectin DC-SIGN tailored cytokine production in response to disti...

journal_title：Nature immunology

authors： Gringhuis SI,den Dunnen J,Litjens M,van der Vlist M,Geijtenbeek TB

更新日期：2009-10-01 00:00:00

abstract：:T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects....

journal_title：Nature immunology

authors： Ishimaru N,Kishimoto H,Hayashi Y,Sprent J

更新日期：2006-07-01 00:00:00

abstract：:Myxoma virus, a member of the poxvirus family, causes lethal infection only in rabbits, but the mechanism underlying the strict myxoma virus species barrier is not known. Here we show that myxoma virus infection of primary mouse embryo fibroblasts elicited extracellular signal-regulated kinase (Erk) signaling, which w...

journal_title：Nature immunology

authors： Wang F,Ma Y,Barrett JW,Gao X,Loh J,Barton E,Virgin HW,McFadden G

更新日期：2004-12-01 00:00:00

abstract：:The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of m...

journal_title：Nature immunology

authors： Zhu C,Chen W,Lou J,Rittase W,Li K

更新日期：2019-10-01 00:00:00

abstract：:During the productive interaction of T cells with antigen-presenting cells (APCs), engaged receptors, including the T cell antigen receptors and their associated tyrosine kinases, assemble into spatially segregated supramolecular activation clusters (SMACs) at the area of cell contact. Here, we studied intracellular s...

journal_title：Nature immunology

authors： Freiberg BA,Kupfer H,Maslanik W,Delli J,Kappler J,Zaller DM,Kupfer A

更新日期：2002-10-01 00:00:00

abstract：:Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intra...

journal_title：Nature immunology

authors： Huang LR,Wohlleber D,Reisinger F,Jenne CN,Cheng RL,Abdullah Z,Schildberg FA,Odenthal M,Dienes HP,van Rooijen N,Schmitt E,Garbi N,Croft M,Kurts C,Kubes P,Protzer U,Heikenwalder M,Knolle PA

更新日期：2013-06-01 00:00:00

abstract：:Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In add...

journal_title：Nature immunology

authors： Shibutani ST,Saitoh T,Nowag H,Münz C,Yoshimori T

更新日期：2015-10-01 00:00:00

abstract：:The inhibitory signaling of natural killer (NK) cells is crucial in the regulation of innate immune responses. Here we show that the association of KIR2DL1, an inhibitory receptor of NK cells, with beta-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated 'downstream'...

journal_title：Nature immunology

authors： Yu MC,Su LL,Zou L,Liu Y,Wu N,Kong L,Zhuang ZH,Sun L,Liu HP,Hu JH,Li D,Strominger JL,Zang JW,Pei G,Ge BX

更新日期：2008-08-01 00:00:00

abstract：:Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of...

journal_title：Nature immunology

authors： Zhou H,Wang H,Yu M,Schugar RC,Qian W,Tang F,Liu W,Yang H,McDowell RE,Zhao J,Gao J,Dongre A,Carman JA,Yin M,Drazba JA,Dent R,Hine C,Chen YR,Smith JD,Fox PL,Brown JM,Li X

更新日期：2020-10-01 00:00:00

abstract：:T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth respo...

journal_title：Nature immunology

authors： Safford M,Collins S,Lutz MA,Allen A,Huang CT,Kowalski J,Blackford A,Horton MR,Drake C,Schwartz RH,Powell JD

更新日期：2005-05-01 00:00:00

abstract：:Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely how TCR signals are channeled toward specific targets remains unclear. TCR stimulation triggers 'alternative' activation of the mitogen-activated protein kinas...

journal_title：Nature immunology

authors： Round JL,Humphries LA,Tomassian T,Mittelstadt P,Zhang M,Miceli MC

更新日期：2007-02-01 00:00:00

abstract：:Myelin basic protein-specific CD8(+) T cells can induce central nervous system autoimmunity; however, immune tolerance prevents these autoreactive cells from causing disease. To define the mechanisms that mediate tolerance, we developed two T cell receptor-transgenic mouse lines with different affinities for the H-2K(...

journal_title：Nature immunology

authors： Perchellet A,Stromnes I,Pang JM,Goverman J

更新日期：2004-06-01 00:00:00

abstract：:Although tissue-resident memory T cells (TRM cells) have been shown to regulate host protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains to be investigated. Here we characterized TRM cells in human IBD and in experimental models of intestinal inflammation. Pro-inflammatory TR...

journal_title：Nature immunology

authors： Zundler S,Becker E,Spocinska M,Slawik M,Parga-Vidal L,Stark R,Wiendl M,Atreya R,Rath T,Leppkes M,Hildner K,López-Posadas R,Lukassen S,Ekici AB,Neufert C,Atreya I,van Gisbergen KPJM,Neurath MF

更新日期：2019-03-01 00:00:00

abstract：:According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, wi...

journal_title：Nature immunology

authors： Drissen R,Buza-Vidas N,Woll P,Thongjuea S,Gambardella A,Giustacchini A,Mancini E,Zriwil A,Lutteropp M,Grover A,Mead A,Sitnicka E,Jacobsen SEW,Nerlov C

更新日期：2016-06-01 00:00:00