Abstract:
:Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish transplantation tolerance. They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Sakaguchi Sdoi
10.1038/ni1178keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
345-52issue
4eissn
1529-2908issn
1529-2916pii
ni1178journal_volume
6pub_type
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