当前位置： SCI文献检索 > NATURE IMMUNOLOGY期刊下所有文献 > CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.

CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.

Abstract：

:During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differentiation of these cells, which we have called 'follicular cytotoxic T cells' (TFC cells), required the transcription factors Bcl6, E2A and TCF-1 but was inhibited by the transcriptional regulators Blimp1, Id2 and Id3. Blimp1 and E2A directly regulated Cxcr5 expression and, together with Bcl6 and TCF-1, formed a transcriptional circuit that guided TFC cell development. The identification of TFC cells has far-reaching implications for the development of strategies to control infections that target B cells and TFH cells and to treat B cell-derived malignancies.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Leong YA,Chen Y,Ong HS,Wu D,Man K,Deleage C,Minnich M,Meckiff BJ,Wei Y,Hou Z,Zotos D,Fenix KA,Atnerkar A,Preston S,Chipman JG,Beilman GJ,Allison CC,Sun L,Wang P,Xu J,Toe JG,Lu HK,Tao Y,Palendira U,Dent AL

doi

10.1038/ni.3543

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

1187-96

issue

10

eissn

1529-2908

issn

1529-2916

pii

ni.3543

journal_volume

17

pub_type

杂志文章

相关文献

NATURE IMMUNOLOGY文献大全
  • Second signals rescue B cells from activation-induced mitochondrial dysfunction and death.

    abstract：:B cells are activated by two temporally distinct signals, the first provided by the binding of antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells. Here we found that B cells responded to antigen by rapidly increasing their metabolic activity, including both oxidative phosphorylatio...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-018-0156-5

    authors： Akkaya M,Traba J,Roesler AS,Miozzo P,Akkaya B,Theall BP,Sohn H,Pena M,Smelkinson M,Kabat J,Dahlstrom E,Dorward DW,Skinner J,Sack MN,Pierce SK

    更新日期：2018-08-01 00:00:00

  • Cytokine-secreting follicular T cells shape the antibody repertoire.

    abstract：:High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell-dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4-reporter system, we show here that CD4(+) foll...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1715

    authors： Reinhardt RL,Liang HE,Locksley RM

    更新日期：2009-04-01 00:00:00

  • HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.

    abstract：:It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and pro...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni845

    authors： Migueles SA,Laborico AC,Shupert WL,Sabbaghian MS,Rabin R,Hallahan CW,Van Baarle D,Kostense S,Miedema F,McLaughlin M,Ehler L,Metcalf J,Liu S,Connors M

    更新日期：2002-11-01 00:00:00

  • A guiding map for inflammation.

    abstract：:Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific o...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3790

    authors： Netea MG,Balkwill F,Chonchol M,Cominelli F,Donath MY,Giamarellos-Bourboulis EJ,Golenbock D,Gresnigt MS,Heneka MT,Hoffman HM,Hotchkiss R,Joosten LAB,Kastner DL,Korte M,Latz E,Libby P,Mandrup-Poulsen T,Mantovani A,Mills

    更新日期：2017-07-19 00:00:00

  • Tissue-resident macrophages.

    abstract：:Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill tissue-specific and niche-specific functions. These range from dedicated homeostatic functions, such as clearance of cellular debris and iron processing, to central roles in tissue immune surveillance, response to infection and the...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.2705

    authors： Davies LC,Jenkins SJ,Allen JE,Taylor PR

    更新日期：2013-10-01 00:00:00

  • IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.

    abstract：:Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structure, the SEFIR-bind...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-018-0071-9

    authors： Herjan T,Hong L,Bubenik J,Bulek K,Qian W,Liu C,Li X,Chen X,Yang H,Ouyang S,Zhou H,Zhao J,Vasu K,Cockman E,Aronica M,Asosingh K,Licatalosi DD,Qin J,Fox PL,Hamilton TA,Driscoll D,Li X

    更新日期：2018-04-01 00:00:00

  • Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.

    abstract：:Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely how TCR signals are channeled toward specific targets remains unclear. TCR stimulation triggers 'alternative' activation of the mitogen-activated protein kinas...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1422

    authors： Round JL,Humphries LA,Tomassian T,Mittelstadt P,Zhang M,Miceli MC

    更新日期：2007-02-01 00:00:00

  • CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.

    abstract：:The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/76957

    authors： Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher A

    更新日期：2000-07-01 00:00:00

  • The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.

    abstract：:The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-kappaB; however, little is known about the mechanisms of A20-mediated inactivation of signaling intermediates such as RIP1. Here we demonstrate that the regulatory molecule ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1563

    authors： Shembade N,Harhaj NS,Parvatiyar K,Copeland NG,Jenkins NA,Matesic LE,Harhaj EW

    更新日期：2008-03-01 00:00:00

  • Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation.

    abstract：:Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor cells suggests additional underlying mechanisms. Here we profiled the genome-wide histone modification...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3706

    authors： Yu B,Zhang K,Milner JJ,Toma C,Chen R,Scott-Browne JP,Pereira RM,Crotty S,Chang JT,Pipkin ME,Wang W,Goldrath AW

    更新日期：2017-05-01 00:00:00

  • 'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations.

    abstract：:Effective clinical cancer immunotherapies, such as administration of the cytokine IL-2, adoptive cell transfer (ACT) and the recent success of blockade of the checkpoint modulators CTLA-4 and PD-1, have been developed without clear identification of the immunogenic targets expressed by human cancers in vivo. Immunothe...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.3682

    authors： Tran E,Robbins PF,Rosenberg SA

    更新日期：2017-02-15 00:00:00

  • The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.

    abstract：:In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2981

    authors： Lanna A,Henson SM,Escors D,Akbar AN

    更新日期：2014-10-01 00:00:00

  • Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation.

    abstract：:CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. We used mice that were transgenic for one of two human CD46 isoforms that differ in their cytoplasmic domains (termed CD46-1 and CD46-2) to analyze the effect of CD46 stimulation ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni810

    authors： Marie JC,Astier AL,Rivailler P,Rabourdin-Combe C,Wild TF,Horvat B

    更新日期：2002-07-01 00:00:00

  • Immunological complications of obesity.

    abstract：:Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved unders...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2343

    authors： Kanneganti TD,Dixit VD

    更新日期：2012-07-19 00:00:00

  • Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

    abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3716

    authors： Katerndahl CDS,Heltemes-Harris LM,Willette MJL,Henzler CM,Frietze S,Yang R,Schjerven H,Silverstein KAT,Ramsey LB,Hubbard G,Wells AD,Kuiper RP,Scheijen B,van Leeuwen FN,Müschen M,Kornblau SM,Farrar MA

    更新日期：2017-06-01 00:00:00

  • Multiple layers of B cell memory with different effector functions.

    abstract：:Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1814

    authors： Dogan I,Bertocci B,Vilmont V,Delbos F,Mégret J,Storck S,Reynaud CA,Weill JC

    更新日期：2009-12-01 00:00:00

  • ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).

    abstract：:Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonst...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1983

    authors： Li Z,Zhang Y,Liu Z,Wu X,Zheng Y,Tao Z,Mao K,Wang J,Lin G,Tian L,Ji Y,Qin M,Sun S,Zhu X,Sun B

    更新日期：2011-02-01 00:00:00

  • Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

    abstract：:The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transducti...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1040

    authors： Liu X,Bosselut R

    更新日期：2004-03-01 00:00:00

  • Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.

    abstract：:The extracellular protein Spätzle is required for activation of the Toll signaling pathway in the embryonic development and innate immune defense of Drosophila. Spätzle is synthesized as a pro-protein and is processed to a functional form by a serine protease. We show here that the mature form of Spätzle triggers a To...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni955

    authors： Weber AN,Tauszig-Delamasure S,Hoffmann JA,Lelièvre E,Gascan H,Ray KP,Morse MA,Imler JL,Gay NJ

    更新日期：2003-08-01 00:00:00

  • Epigenetic control of innate and adaptive immune memory.

    abstract：:Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate t...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-018-0176-1

    authors： Lau CM,Adams NM,Geary CD,Weizman OE,Rapp M,Pritykin Y,Leslie CS,Sun JC

    更新日期：2018-09-01 00:00:00

  • Programmed necrosis: backup to and competitor with apoptosis in the immune system.

    abstract：:Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed c...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.2159

    authors： Han J,Zhong CQ,Zhang DW

    更新日期：2011-11-16 00:00:00

  • Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction.

    abstract：:Autophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18. Here we show that the induction of AIM2 or NLRP3 inflammasomes in...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2215

    authors： Shi CS,Shenderov K,Huang NN,Kabat J,Abu-Asab M,Fitzgerald KA,Sher A,Kehrl JH

    更新日期：2012-01-29 00:00:00

  • RabGEF1 is a negative regulator of mast cell activation and skin inflammation.

    abstract：:Mast cell activation induced by aggregation of Fc epsilon RI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1093

    authors： Tam SY,Tsai M,Snouwaert JN,Kalesnikoff J,Scherrer D,Nakae S,Chatterjea D,Bouley DM,Galli SJ

    更新日期：2004-08-01 00:00:00

  • ER aminopeptidases generate a unique pool of peptides for MHC class I molecules.

    abstract：:We define here the specificity and significance of proteases in the endoplasmic reticulum (ER) that generate peptides for presentation by major histocompatibility complex (MHC) class I molecules. We show that aminopeptidases efficiently trimmed all residues except proline that flank the NH2-termini of antigenic precur...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/89800

    authors： Serwold T,Gaw S,Shastri N

    更新日期：2001-07-01 00:00:00

  • Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.

    abstract：:Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni817

    authors： Parravicini V,Gadina M,Kovarova M,Odom S,Gonzalez-Espinosa C,Furumoto Y,Saitoh S,Samelson LE,O'Shea JJ,Rivera J

    更新日期：2002-08-01 00:00:00

  • Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

    abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

    journal_title：Nature immunology

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/ni1117-1271c

    authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

    更新日期：2017-10-18 00:00:00

  • The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.

    abstract：:The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1883

    authors： Tang H,Cao W,Kasturi SP,Ravindran R,Nakaya HI,Kundu K,Murthy N,Kepler TB,Malissen B,Pulendran B

    更新日期：2010-07-01 00:00:00

  • Mechanisms and consequences of Jak-STAT signaling in the immune system.

    abstract：:Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal transducer and activator of transcription') family constitute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune system. Research on this paradigmatic pathway has experienced brea...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.3691

    authors： Villarino AV,Kanno Y,O'Shea JJ

    更新日期：2017-03-22 00:00:00

  • Production of an antigenic peptide by insulin-degrading enzyme.

    abstract：:Most antigenic peptides presented by major histocompatibility complex (MHC) class I molecules are produced by the proteasome. Here we show that a proteasome-independent peptide derived from the human tumor protein MAGE-A3 is produced directly by insulin-degrading enzyme (IDE), a cytosolic metallopeptidase. Cytotoxic T...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1862

    authors： Parmentier N,Stroobant V,Colau D,de Diesbach P,Morel S,Chapiro J,van Endert P,Van den Eynde BJ

    更新日期：2010-05-01 00:00:00

  • Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance.

    abstract：:Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3053

    authors： Yu F,Sharma S,Edwards J,Feigenbaum L,Zhu J

    更新日期：2015-02-01 00:00:00