Abstract:
:It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and progressors, only those of nonprogressors maintained a high proliferative capacity. This proliferation was coupled to increases in perforin expression. These results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function. In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Migueles SA,Laborico AC,Shupert WL,Sabbaghian MS,Rabin R,Hallahan CW,Van Baarle D,Kostense S,Miedema F,McLaughlin M,Ehler L,Metcalf J,Liu S,Connors Mdoi
10.1038/ni845keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1061-8issue
11eissn
1529-2908issn
1529-2916pii
ni845journal_volume
3pub_type
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