Abstract:
:We have identified a silencer and an antisilencing element that interact at a distance of 85 kilobases to regulate expression of the recombination activating genes Rag1 and Rag2 in thymocytes. Transgenic experiments showed that Rag promoter-proximal cis elements directed tissue-specific expression and that a Runx-dependent intergenic silencer suppressed expression in developing T cells. Deletion of the antisilencing element from the genomic Rag locus unmasked the intergenic silencer and abrogated Rag expression in developing CD4(+)CD8(+) T cells. We speculate that the Rag antisilencing element belongs to a class of cis elements that might be useful for genome diversification by activating genes encoded by otherwise silent transposable elements.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Yannoutsos N,Barreto V,Misulovin Z,Gazumyan A,Yu W,Rajewsky N,Peixoto BR,Eisenreich T,Nussenzweig MCdoi
10.1038/ni1053keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
443-50issue
4eissn
1529-2908issn
1529-2916pii
ni1053journal_volume
5pub_type
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