Immunopathology of highly virulent pathogens: insights from Ebola virus.

abstract：:Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators. ...

journal_title：Nature immunology

authors： Singh H

更新日期：2007-02-01 00:00:00

abstract：:Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals remains poorly understood. In this study, we identified the ubiquitin-specific protease USP25 as a negative regulator of IL-17-mediated signaling and inflammation. Overexpression of USP25 inhibited IL-17-triggered signaling, whereas USP2...

journal_title：Nature immunology

authors： Zhong B,Liu X,Wang X,Chang SH,Liu X,Wang A,Reynolds JM,Dong C

更新日期：2012-11-01 00:00:00

abstract：:The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell b...

journal_title：Nature immunology

authors： Dustin ML,Cooper JA

更新日期：2000-07-01 00:00:00

abstract：:Mice deficient in the adaptor Ndfip1 develop inflammation at sites of environmental antigen exposure. We show here that such mice had fewer inducible regulatory T cells (iT(reg) cells). In vitro, Ndfip1-deficient T cells expressed normal amounts of the transcription factor Foxp3 during the first 48 h of iT(reg) cell d...

journal_title：Nature immunology

authors： Beal AM,Ramos-Hernández N,Riling CR,Nowelsky EA,Oliver PM

更新日期：2011-11-13 00:00:00

abstract：:The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoi...

journal_title：Nature immunology

authors： van de Pavert SA,Olivier BJ,Goverse G,Vondenhoff MF,Greuter M,Beke P,Kusser K,Höpken UE,Lipp M,Niederreither K,Blomhoff R,Sitnik K,Agace WW,Randall TD,de Jonge WJ,Mebius RE

更新日期：2009-11-01 00:00:00

abstract：:Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threa...

journal_title：Nature immunology

authors： Weisberg SP,Connors TJ,Zhu Y,Baldwin MR,Lin WH,Wontakal S,Szabo PA,Wells SB,Dogra P,Gray J,Idzikowski E,Stelitano D,Bovier FT,Davis-Porada J,Matsumoto R,Poon MML,Chait M,Mathieu C,Horvat B,Decimo D,Hudson KE,Zot

更新日期：2021-01-01 00:00:00

abstract：:Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch receptors, augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of classic...

journal_title：Nature immunology

authors： Xu H,Zhu J,Smith S,Foldi J,Zhao B,Chung AY,Outtz H,Kitajewski J,Shi C,Weber S,Saftig P,Li Y,Ozato K,Blobel CP,Ivashkiv LB,Hu X

更新日期：2012-05-20 00:00:00

abstract：:The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T(H)-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS...

journal_title：Nature immunology

authors： Zhang F,Meng G,Strober W

更新日期：2008-11-01 00:00:00

abstract：:By genetically ablating IkappaB kinase (IKK)-mediated activation of the transcription factor NF-kappaB in the B cell lineage and by analyzing a mouse mutant in which immunoglobulin lambda-chain-positive B cells are generated in the absence of rearrangements in the locus encoding immunoglobulin kappa-chain, we define h...

journal_title：Nature immunology

authors： Derudder E,Cadera EJ,Vahl JC,Wang J,Fox CJ,Zha S,van Loo G,Pasparakis M,Schlissel MS,Schmidt-Supprian M,Rajewsky K

更新日期：2009-06-01 00:00:00

abstract：:Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for...

journal_title：Nature immunology

authors： Parravicini V,Gadina M,Kovarova M,Odom S,Gonzalez-Espinosa C,Furumoto Y,Saitoh S,Samelson LE,O'Shea JJ,Rivera J

更新日期：2002-08-01 00:00:00

abstract：:Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from ...

journal_title：Nature immunology

authors： Reeves RK,Li H,Jost S,Blass E,Li H,Schafer JL,Varner V,Manickam C,Eslamizar L,Altfeld M,von Andrian UH,Barouch DH

更新日期：2015-09-01 00:00:00

abstract：:In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article. ...

journal_title：Nature immunology

authors： Zemmour D,Zilionis R,Kiner E,Klein AM,Mathis D,Benoist C

更新日期：2018-06-01 00:00:00

abstract：:The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...

journal_title：Nature immunology

authors： Stumhofer JS,Tait ED,Quinn WJ 3rd,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate...

journal_title：Nature immunology

authors： Iversen MB,Reinert LS,Thomsen MK,Bagdonaite I,Nandakumar R,Cheshenko N,Prabakaran T,Vakhrushev SY,Krzyzowska M,Kratholm SK,Ruiz-Perez F,Petersen SV,Goriely S,Bibby BM,Eriksson K,Ruland J,Thomsen AR,Herold BC,Wandall H

更新日期：2016-02-01 00:00:00

abstract：:Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the...

journal_title：Nature immunology

authors： Yu F,Sharma S,Edwards J,Feigenbaum L,Zhu J

更新日期：2015-02-01 00:00:00

abstract：:Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR)...

journal_title：Nature immunology

authors： Quann EJ,Liu X,Altan-Bonnet G,Huse M

更新日期：2011-05-22 00:00:00

abstract：:Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human c...

journal_title：Nature immunology

authors： Slevogt H,Zabel S,Opitz B,Hocke A,Eitel J,N'guessan PD,Lucka L,Riesbeck K,Zimmermann W,Zweigner J,Temmesfeld-Wollbrueck B,Suttorp N,Singer BB

更新日期：2008-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Zhu C,Chen W,Lou J,Rittase W,Li K

更新日期：2019-12-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2018-07-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

journal_title：Nature immunology

authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

更新日期：2017-10-18 00:00:00

abstract：:We define here the specificity and significance of proteases in the endoplasmic reticulum (ER) that generate peptides for presentation by major histocompatibility complex (MHC) class I molecules. We show that aminopeptidases efficiently trimmed all residues except proline that flank the NH2-termini of antigenic precur...

journal_title：Nature immunology

authors： Serwold T,Gaw S,Shastri N

更新日期：2001-07-01 00:00:00

abstract：:We evaluated changes in the signaling potentials and proliferative capacity of single antigen-specific T helper (TH) cells during a primary immune response to a protein antigen. At the peak of cellular expansion in vivo all antigen-specific TH cells exhibited a profound block in CD3- and CD4-mediated mobilization of i...

journal_title：Nature immunology

authors： Bikah G,Pogue-Caley RR,McHeyzer-Williams LJ,McHeyzer-Williams MG

更新日期：2000-11-01 00:00:00

abstract：:Dendritic cells (DCs) initiate and regulate immunity against foreign and self antigens. Here we identified more than 200 individual major histocompatibility complex class II-associated peptides on human DCs and found that mature DCs selectively upregulated the self peptide CLIP. CLIP cosegregated together with foreign...

journal_title：Nature immunology

authors： Röhn TA,Boes M,Wolters D,Spindeldreher S,Müller B,Langen H,Ploegh H,Vogt AB,Kropshofer H

更新日期：2004-09-01 00:00:00

abstract：:Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokin...

journal_title：Nature immunology

authors： Tripp RA,Jones LP,Haynes LM,Zheng H,Murphy PM,Anderson LJ

更新日期：2001-08-01 00:00:00

abstract：:Transcriptome profiling is widely used to infer functional states of specific cell types, as well as their responses to stimuli, to define contributions to physiology and pathophysiology. Focusing on microglia, the brain's macrophages, we report here a side-by-side comparison of classical cell-sorting-based transcript...

journal_title：Nature immunology

authors： Haimon Z,Volaski A,Orthgiess J,Boura-Halfon S,Varol D,Shemer A,Yona S,Zuckerman B,David E,Chappell-Maor L,Bechmann I,Gericke M,Ulitsky I,Jung S

更新日期：2018-06-01 00:00:00

abstract：:Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...

journal_title：Nature immunology

authors： Jeltsch KM,Hu D,Brenner S,Zöller J,Heinz GA,Nagel D,Vogel KU,Rehage N,Warth SC,Edelmann SL,Gloury R,Martin N,Lohs C,Lech M,Stehklein JE,Geerlof A,Kremmer E,Weber A,Anders HJ,Schmitz I,Schmidt-Supprian M,Fu M,H

更新日期：2014-11-01 00:00:00

abstract：:Effective clinical cancer immunotherapies, such as administration of the cytokine IL-2, adoptive cell transfer (ACT) and the recent success of blockade of the checkpoint modulators CTLA-4 and PD-1, have been developed without clear identification of the immunogenic targets expressed by human cancers in vivo. Immunothe...

journal_title：Nature immunology

authors： Tran E,Robbins PF,Rosenberg SA

更新日期：2017-02-15 00:00:00

abstract：:Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiatio...

journal_title：Nature immunology

authors： Tanigaki K,Honjo T

更新日期：2007-05-01 00:00:00

abstract：:We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...

journal_title：Nature immunology

authors： Kotenko SV,Gallagher G,Baurin VV,Lewis-Antes A,Shen M,Shah NK,Langer JA,Sheikh F,Dickensheets H,Donnelly RP

更新日期：2003-01-01 00:00:00

abstract：:The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR ne...

journal_title：Nature immunology

authors： Sakaguchi S,Hombauer M,Bilic I,Naoe Y,Schebesta A,Taniuchi I,Ellmeier W

更新日期：2010-05-01 00:00:00