Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.

abstract：:Dendritic cells (DCs) initiate and regulate immunity against foreign and self antigens. Here we identified more than 200 individual major histocompatibility complex class II-associated peptides on human DCs and found that mature DCs selectively upregulated the self peptide CLIP. CLIP cosegregated together with foreign...

journal_title：Nature immunology

authors： Röhn TA,Boes M,Wolters D,Spindeldreher S,Müller B,Langen H,Ploegh H,Vogt AB,Kropshofer H

更新日期：2004-09-01 00:00:00

abstract：:Although tissue-resident memory T cells (TRM cells) have been shown to regulate host protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains to be investigated. Here we characterized TRM cells in human IBD and in experimental models of intestinal inflammation. Pro-inflammatory TR...

journal_title：Nature immunology

authors： Zundler S,Becker E,Spocinska M,Slawik M,Parga-Vidal L,Stark R,Wiendl M,Atreya R,Rath T,Leppkes M,Hildner K,López-Posadas R,Lukassen S,Ekici AB,Neufert C,Atreya I,van Gisbergen KPJM,Neurath MF

更新日期：2019-03-01 00:00:00

abstract：:The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cell...

journal_title：Nature immunology

authors： Delconte RB,Kolesnik TB,Dagley LF,Rautela J,Shi W,Putz EM,Stannard K,Zhang JG,Teh C,Firth M,Ushiki T,Andoniou CE,Degli-Esposti MA,Sharp PP,Sanvitale CE,Infusini G,Liau NP,Linossi EM,Burns CJ,Carotta S,Gray DH,Se

更新日期：2016-07-01 00:00:00

abstract：:Transcriptome profiling is widely used to infer functional states of specific cell types, as well as their responses to stimuli, to define contributions to physiology and pathophysiology. Focusing on microglia, the brain's macrophages, we report here a side-by-side comparison of classical cell-sorting-based transcript...

journal_title：Nature immunology

authors： Haimon Z,Volaski A,Orthgiess J,Boura-Halfon S,Varol D,Shemer A,Yona S,Zuckerman B,David E,Chappell-Maor L,Bechmann I,Gericke M,Ulitsky I,Jung S

更新日期：2018-06-01 00:00:00

abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...

journal_title：Nature immunology

authors： Katerndahl CDS,Heltemes-Harris LM,Willette MJL,Henzler CM,Frietze S,Yang R,Schjerven H,Silverstein KAT,Ramsey LB,Hubbard G,Wells AD,Kuiper RP,Scheijen B,van Leeuwen FN,Müschen M,Kornblau SM,Farrar MA

更新日期：2017-06-01 00:00:00

abstract：:The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immun...

journal_title：Nature immunology

authors： Hansen TH,Huang S,Arnold PL,Fremont DH

更新日期：2007-06-01 00:00:00

abstract：:Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. Here we used ASK1-deficient mice to show that ASK1 was selectively required for lipopolysaccharide-induced activation of p38 but not of Jnk or...

journal_title：Nature immunology

authors： Matsuzawa A,Saegusa K,Noguchi T,Sadamitsu C,Nishitoh H,Nagai S,Koyasu S,Matsumoto K,Takeda K,Ichijo H

更新日期：2005-06-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

journal_title：Nature immunology

authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

更新日期：2017-10-18 00:00:00

abstract：:The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transducti...

journal_title：Nature immunology

authors： Liu X,Bosselut R

更新日期：2004-03-01 00:00:00

abstract：:The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...

journal_title：Nature immunology

authors： Bender TP,Kremer CS,Kraus M,Buch T,Rajewsky K

更新日期：2004-07-01 00:00:00

abstract：:Phagocytosis has essential functions in immunity. Here we highlight the presence of a subcellular level of self-non-self discrimination in dendritic cells that operates at the level of individual phagosomes. We discuss how engagement of Toll-like receptor signaling controls distinct programs of phagosome maturation. A...

journal_title：Nature immunology

authors： Blander JM,Medzhitov R

更新日期：2006-10-01 00:00:00

abstract：:TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation of invariant natural killer T cells (iNKT cells). Tet2-Tet3 doub...

journal_title：Nature immunology

authors： Tsagaratou A,González-Avalos E,Rautio S,Scott-Browne JP,Togher S,Pastor WA,Rothenberg EV,Chavez L,Lähdesmäki H,Rao A

更新日期：2017-01-01 00:00:00

abstract：:The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and c...

journal_title：Nature immunology

authors： Wyss L,Stadinski BD,King CG,Schallenberg S,McCarthy NI,Lee JY,Kretschmer K,Terracciano LM,Anderson G,Surh CD,Huseby ES,Palmer E

更新日期：2016-09-01 00:00:00

abstract：:After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...

journal_title：Nature immunology

authors： Henrickson SE,Mempel TR,Mazo IB,Liu B,Artyomov MN,Zheng H,Peixoto A,Flynn MP,Senman B,Junt T,Wong HC,Chakraborty AK,von Andrian UH

更新日期：2008-03-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2019-01-01 00:00:00

abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

journal_title：Nature immunology

authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

更新日期：2004-01-01 00:00:00

abstract：:The inhibitory signaling of natural killer (NK) cells is crucial in the regulation of innate immune responses. Here we show that the association of KIR2DL1, an inhibitory receptor of NK cells, with beta-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated 'downstream'...

journal_title：Nature immunology

authors： Yu MC,Su LL,Zou L,Liu Y,Wu N,Kong L,Zhuang ZH,Sun L,Liu HP,Hu JH,Li D,Strominger JL,Zang JW,Pei G,Ge BX

更新日期：2008-08-01 00:00:00

abstract：:CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gen...

journal_title：Nature immunology

authors： Shimizu J,Yamazaki S,Takahashi T,Ishida Y,Sakaguchi S

更新日期：2002-02-01 00:00:00

abstract：:Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell receptor internalizat...

journal_title：Nature immunology

authors： Gomez TS,Hamann MJ,McCarney S,Savoy DN,Lubking CM,Heldebrant MP,Labno CM,McKean DJ,McNiven MA,Burkhardt JK,Billadeau DD

更新日期：2005-03-01 00:00:00

abstract：:Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish ...

journal_title：Nature immunology

authors： Sakaguchi S

更新日期：2005-04-01 00:00:00

abstract：:Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism selectively abolishes the expression of ACKR1 in erythroid cells, causing a Duffy-negative phenotype. Here we describe an unexpected ...

journal_title：Nature immunology

authors： Duchene J,Novitzky-Basso I,Thiriot A,Casanova-Acebes M,Bianchini M,Etheridge SL,Hub E,Nitz K,Artinger K,Eller K,Caamaño J,Rülicke T,Moss P,Megens RTA,von Andrian UH,Hidalgo A,Weber C,Rot A

更新日期：2017-07-01 00:00:00

abstract：:Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to i...

journal_title：Nature immunology

authors： Aaby P,Kollmann TR,Benn CS

更新日期：2014-10-01 00:00:00

abstract：:The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi...

journal_title：Nature immunology

authors： Leulier F,Parquet C,Pili-Floury S,Ryu JH,Caroff M,Lee WJ,Mengin-Lecreulx D,Lemaitre B

更新日期：2003-05-01 00:00:00

abstract：:Upregulation of the inducible gene products MICA (human) and Rae-1 (mouse) may promote tumor surveillance and autoimmunity by engaging the activating receptor NKG2D on natural killer (NK) cells and T cells. Nevertheless, sustained expression of MICA by tumors can also elicit NKG2D downregulation, perhaps indicating 'i...

journal_title：Nature immunology

authors： Oppenheim DE,Roberts SJ,Clarke SL,Filler R,Lewis JM,Tigelaar RE,Girardi M,Hayday AC

更新日期：2005-09-01 00:00:00

abstract：:As a result of decades of research-driven breakthroughs in basic and clinical science and recent advances in the broad-scale implementation of interventions for the prevention and treatment of infection with HIV, a turning point has been reached in the global HIV-AIDS pandemic. To end the pandemic and achieve the goal...

journal_title：Nature immunology

authors： Fauci AS,Folkers GK,Dieffenbach CW

更新日期：2013-11-01 00:00:00

abstract：:Evidence suggests that regulatory T cells expressing the transcription factor Foxp3 develop extrathymically and intrathymically. Mechanisms of extrathymic induction require further scrutiny, especially as proliferation and/or phenotypic changes of preexisting suppressor cells must be distinguished from true de novo ge...

journal_title：Nature immunology

authors： Kretschmer K,Apostolou I,Hawiger D,Khazaie K,Nussenzweig MC,von Boehmer H

更新日期：2005-12-01 00:00:00

abstract：:Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill tissue-specific and niche-specific functions. These range from dedicated homeostatic functions, such as clearance of cellular debris and iron processing, to central roles in tissue immune surveillance, response to infection and the...

journal_title：Nature immunology

authors： Davies LC,Jenkins SJ,Allen JE,Taylor PR

更新日期：2013-10-01 00:00:00

abstract：:Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found tha...

journal_title：Nature immunology

authors： Tellier J,Shi W,Minnich M,Liao Y,Crawford S,Smyth GK,Kallies A,Busslinger M,Nutt SL

更新日期：2016-03-01 00:00:00

abstract：:Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditions that allow the stimulatory presentation of self peptides themselves and that this might suffice to elicit autoreactive T ce...

journal_title：Nature immunology

authors： Campisi L,Barbet G,Ding Y,Esplugues E,Flavell RA,Blander JM

更新日期：2016-09-01 00:00:00

abstract：:In the version of this article initially published, some identification of the supplementary information was incorrect. The items originally called Supplementary Tables 1, 2, 3, 4 and 5 should be Source Data Figures 1, 2, 4, 5 and 7, respectively; those originally called Supplementary Tables 6, 7 and 8 should be Suppl...

journal_title：Nature immunology

authors： Zhang M,Dong Y,Hu F,Yang D,Zhao Q,Lv C,Wang Y,Xia C,Weng Q,Liu X,Li C,Zhou P,Wang T,Guan Y,Guo R,Liu L,Geng Y,Wu H,Du J,Hu Z,Xu S,Chen J,He A,Liu B,Wang D,Yang YG,Wang J

更新日期：2018-09-01 00:00:00