Abstract:
:Although tissue-resident memory T cells (TRM cells) have been shown to regulate host protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains to be investigated. Here we characterized TRM cells in human IBD and in experimental models of intestinal inflammation. Pro-inflammatory TRM cells accumulated in the mucosa of patients with IBD, and the presence of CD4+CD69+CD103+ TRM cells was predictive of the development of flares. In vivo, functional impairment of TRM cells in mice with double knockout of the TRM-cell-associated transcription factors Hobit and Blimp-1 attenuated disease in several models of colitis, due to impaired cross-talk between the adaptive and innate immune system. Finally, depletion of TRM cells led to a suppression of colitis activity. Together, our data demonstrate a central role for TRM cells in the pathogenesis of chronic intestinal inflammation and suggest that these cells could be targets for future therapeutic approaches in IBD.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Zundler S,Becker E,Spocinska M,Slawik M,Parga-Vidal L,Stark R,Wiendl M,Atreya R,Rath T,Leppkes M,Hildner K,López-Posadas R,Lukassen S,Ekici AB,Neufert C,Atreya I,van Gisbergen KPJM,Neurath MFdoi
10.1038/s41590-018-0298-5subject
Has Abstractpub_date
2019-03-01 00:00:00pages
288-300issue
3eissn
1529-2908issn
1529-2916pii
10.1038/s41590-018-0298-5journal_volume
20pub_type
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abstract:: ...
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