Abstract:
:
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Park JY,Park JHdoi
10.1038/s41590-018-0240-xsubject
pub_date
2018-11-01 00:00:00pages
1152-1154issue
11eissn
1529-2908issn
1529-2916pii
10.1038/s41590-018-0240-xjournal_volume
19pub_type
评论,杂志文章abstract::The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this di...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni0902-807
更新日期:2002-09-01 00:00:00
abstract::The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hyperm...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1067
更新日期:2004-05-01 00:00:00
abstract::Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human c...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1661
更新日期:2008-11-01 00:00:00
abstract::CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral inter...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1102-1019
更新日期:2002-11-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0476-0
更新日期:2019-10-01 00:00:00
abstract::Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1303
更新日期:2006-02-01 00:00:00
abstract::Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In add...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3273
更新日期:2015-10-01 00:00:00
abstract::T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1321
更新日期:2006-05-01 00:00:00
abstract::An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1706
更新日期:2009-04-01 00:00:00
abstract::After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1559
更新日期:2008-03-01 00:00:00
abstract::STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs. Although STING ER exit is the rate-limiting step in STING signal...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0730-5
更新日期:2020-08-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0545-4
更新日期:2019-12-01 00:00:00
abstract::Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription fact...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0737-y
更新日期:2020-09-01 00:00:00
abstract::Plant proteins belonging to the nucleotide-binding site-leucine-rich repeat (NBS-LRR) family are used for pathogen detection. Like the mammalian Nod-LRR protein 'sensors' that detect intracellular conserved pathogen-associated molecular patterns, plant NBS-LRR proteins detect pathogen-associated proteins, most often t...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1410
更新日期:2006-12-01 00:00:00
abstract::Ebola virus is a highly virulent pathogen capable of inducing a frequently lethal hemorrhagic fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate and adaptive immune responses and triggers harmful inflammatory responses as it inflicts direct tissue damage. The host immune syste...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1519
更新日期:2007-11-01 00:00:00
abstract::Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding pro...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0697-2
更新日期:2020-08-01 00:00:00
abstract::Interleukin 17 (IL-17)-producing T helper 17 cells (T(H)-17 cells) have been described as a T helper cell subset distinct from T helper type 1 (T(H)1) and T(H)2 cells, with specific functions in antimicrobial defense and autoimmunity. The factors driving human T(H)-17 differentiation remain controversial. Using a syst...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1613
更新日期:2008-06-01 00:00:00
abstract::B cells are activated by two temporally distinct signals, the first provided by the binding of antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells. Here we found that B cells responded to antigen by rapidly increasing their metabolic activity, including both oxidative phosphorylatio...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0156-5
更新日期:2018-08-01 00:00:00
abstract::Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators. ...
journal_title:Nature immunology
pub_type: 评论,新闻
doi:10.1038/ni0207-119
更新日期:2007-02-01 00:00:00
abstract::The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), tha...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0698-1
更新日期:2020-07-01 00:00:00
abstract::Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of path...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2406
更新日期:2012-10-01 00:00:00
abstract::Although approximately 200 viral microRNAs are known, only very few share similar targets with their host's microRNAs. A notable example of this is the stress-induced ligand MICB, which is targeted by several distinct viral and cellular microRNAs. Through the investigation of the microRNA-mediated immune-evasion strat...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1916
更新日期:2010-09-01 00:00:00
abstract::Antibody specificity and diversity is generated in B cells during germinal center maturation through clonal expansion while they undergo class-switch recombination and somatic hypermutation. Here we demonstrate that the transcriptional repressor Bcl-6 mediates this phenotype by directly repressing ATR in centroblasts ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1478
更新日期:2007-07-01 00:00:00
abstract::B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in hum...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0772-8
更新日期:2020-11-01 00:00:00
abstract::In neutrophils, superoxide anion production generally accompanies chemotaxis and functions in killing invading pathogens. The GIT2 GTPase-activating protein binds to the guanine nucleotide-exchange factor alphaPIX. Here we show that GIT2 was necessary for directional chemotaxis and for the suppression of superoxide pr...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1349
更新日期:2006-07-01 00:00:00
abstract::The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process. ...
journal_title:Nature immunology
pub_type: 评论,杂志文章,评审
doi:10.1038/ni1008-1099
更新日期:2008-10-01 00:00:00
abstract::Tim-3 is a T helper type 1 (T(H)1)-specific cell surface molecule that seems to regulate T(H)1 responses and the induction of peripheral tolerance. However, the identity of the Tim-3 ligand and the mechanism by which this ligand inhibits the function of effector T(H)1 cells remain unknown. Here we show that galectin-9...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1271
更新日期:2005-12-01 00:00:00
abstract::As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni0407-325
更新日期:2007-04-01 00:00:00
abstract::Chemokines facilitate leukocyte migration and positioning as well as other processes such as angiogenesis and leukocyte degranulation. The burgeoning knowledge on chemokines and their receptors has influenced many aspects of immunology, in part because cell migration is intimately related to leukocyte function. This o...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/84298
更新日期:2001-02-01 00:00:00
abstract::CD11b(+) dendritic cells (DCs) seem to be specialized for presenting antigens via major histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and regulatory basis for this is not established. Conditional deletion of Irf4 resulted in loss of CD11b(+) DCs, impaired formation of peptide...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2795
更新日期:2014-02-01 00:00:00