Plant NBS-LRR proteins in pathogen sensing and host defense.

abstract：:Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal...

journal_title：Nature immunology

authors： Povoleri GAM,Nova-Lamperti E,Scottà C,Fanelli G,Chen YC,Becker PD,Boardman D,Costantini B,Romano M,Pavlidis P,McGregor R,Pantazi E,Chauss D,Sun HW,Shih HY,Cousins DJ,Cooper N,Powell N,Kemper C,Pirooznia M,Laurence

更新日期：2018-12-01 00:00:00

abstract：:Susceptibility to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by a variety of genetic and environmental or stochastic factors. After over a decade of linkage analyses, the identification of non-major histocompatibility complex (non-MHC) susceptibility alleles has proved to be difficult, predo...

journal_title：Nature immunology

authors： Wandstrat A,Wakeland E

更新日期：2001-09-01 00:00:00

abstract：:Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct lineages: the CD8α(+) (CD103(+)) cDC1 lineage, and the CD11b(+) cDC2 lineage. cDCs arise from a cascade of bone marrow (BM) DC-committed progenitor cells that include the common DC progenitors (CDPs) and pre-DCs, which exit the ...

journal_title：Nature immunology

authors： Schlitzer A,Sivakamasundari V,Chen J,Sumatoh HR,Schreuder J,Lum J,Malleret B,Zhang S,Larbi A,Zolezzi F,Renia L,Poidinger M,Naik S,Newell EW,Robson P,Ginhoux F

更新日期：2015-07-01 00:00:00

abstract：:HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased pro...

journal_title：Nature immunology

authors： Shui JW,Boomer JS,Han J,Xu J,Dement GA,Zhou G,Tan TH

更新日期：2007-01-01 00:00:00

abstract：:During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on Bcl11b, which encodes a transcription factor. To clarify lineage commitment mechanisms, we followed developing T cells at the single-cell level using Bcl11b knock-in fluorescent repor...

journal_title：Nature immunology

authors： Kueh HY,Yui MA,Ng KK,Pease SS,Zhang JA,Damle SS,Freedman G,Siu S,Bernstein ID,Elowitz MB,Rothenberg EV

更新日期：2016-08-01 00:00:00

abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

journal_title：Nature immunology

authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

更新日期：2005-08-01 00:00:00

abstract：:The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential role in supporting ...

journal_title：Nature immunology

authors： Everts B,Amiel E,Huang SC,Smith AM,Chang CH,Lam WY,Redmann V,Freitas TC,Blagih J,van der Windt GJ,Artyomov MN,Jones RG,Pearce EL,Pearce EJ

更新日期：2014-04-01 00:00:00

abstract：:Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells (DCs) and macrophages. Because there is no precedent for immune receptor signaling in the ER, we investigated how TLR9 is act...

journal_title：Nature immunology

authors： Latz E,Schoenemeyer A,Visintin A,Fitzgerald KA,Monks BG,Knetter CF,Lien E,Nilsen NJ,Espevik T,Golenbock DT

更新日期：2004-02-01 00:00:00

abstract：:Programmed cell death is essential for the development and maintenance of cellular homeostasis of the immune system. The Bcl-2 family of proteins comprises both pro-apoptotic and anti-apoptotic members. A subset of pro-apoptotic members, called 'BH3-only' proteins, share sequence homology only in the minimal death dom...

journal_title：Nature immunology

authors： Opferman JT,Korsmeyer SJ

更新日期：2003-05-01 00:00:00

abstract：:While a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed en...

journal_title：Nature immunology

authors： Saini AS,Shenoy GN,Rath S,Bal V,George A

更新日期：2014-03-01 00:00:00

abstract：:Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-6...

journal_title：Nature immunology

authors： Köhler F,Storch B,Kulathu Y,Herzog S,Kuppig S,Reth M,Jumaa H

更新日期：2005-02-01 00:00:00

abstract：:Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type ...

journal_title：Nature immunology

authors： Kawai T,Akira S

更新日期：2006-02-01 00:00:00

abstract：:Although much is known about the migration of T cells from blood to lymph nodes, less is known about the mechanisms regulating the migration of T cells from tissues into lymph nodes through afferent lymphatics. Here we investigated T cell egress from nonlymphoid tissues into afferent lymph in vivo and developed an exp...

journal_title：Nature immunology

authors： Ledgerwood LG,Lal G,Zhang N,Garin A,Esses SJ,Ginhoux F,Merad M,Peche H,Lira SA,Ding Y,Yang Y,He X,Schuchman EH,Allende ML,Ochando JC,Bromberg JS

更新日期：2008-01-01 00:00:00

abstract：:Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...

journal_title：Nature immunology

authors： Jeltsch KM,Hu D,Brenner S,Zöller J,Heinz GA,Nagel D,Vogel KU,Rehage N,Warth SC,Edelmann SL,Gloury R,Martin N,Lohs C,Lech M,Stehklein JE,Geerlof A,Kremmer E,Weber A,Anders HJ,Schmitz I,Schmidt-Supprian M,Fu M,H

更新日期：2014-11-01 00:00:00

abstract：:CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8(+) T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previousl...

journal_title：Nature immunology

authors： Schenkel JM,Fraser KA,Vezys V,Masopust D

更新日期：2013-05-01 00:00:00

abstract：:In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article. ...

journal_title：Nature immunology

authors： Zemmour D,Zilionis R,Kiner E,Klein AM,Mathis D,Benoist C

更新日期：2018-06-01 00:00:00

abstract：:T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects....

journal_title：Nature immunology

authors： Ishimaru N,Kishimoto H,Hayashi Y,Sprent J

更新日期：2006-07-01 00:00:00

abstract：:More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...

journal_title：Nature immunology

authors： Manz MG,Di Santo JP

更新日期：2009-10-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Park JY,Park JH

更新日期：2018-11-01 00:00:00

abstract：:Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory proteins. The Act1 SEFIR domain binds a stem-loop structure, the SEFIR-bind...

journal_title：Nature immunology

authors： Herjan T,Hong L,Bubenik J,Bulek K,Qian W,Liu C,Li X,Chen X,Yang H,Ouyang S,Zhou H,Zhao J,Vasu K,Cockman E,Aronica M,Asosingh K,Licatalosi DD,Qin J,Fox PL,Hamilton TA,Driscoll D,Li X

更新日期：2018-04-01 00:00:00

abstract：:Upregulation of the inducible gene products MICA (human) and Rae-1 (mouse) may promote tumor surveillance and autoimmunity by engaging the activating receptor NKG2D on natural killer (NK) cells and T cells. Nevertheless, sustained expression of MICA by tumors can also elicit NKG2D downregulation, perhaps indicating 'i...

journal_title：Nature immunology

authors： Oppenheim DE,Roberts SJ,Clarke SL,Filler R,Lewis JM,Tigelaar RE,Girardi M,Hayday AC

更新日期：2005-09-01 00:00:00

abstract：:As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus. ...

journal_title：Nature immunology

authors： Oldstone MB

更新日期：2007-04-01 00:00:00

abstract：:Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...

journal_title：Nature immunology

authors： McKenzie JL,Gan OI,Doedens M,Wang JC,Dick JE

更新日期：2006-11-01 00:00:00

abstract：:Two potential outcomes confront proliferating antigen-stimulated naive T cells: differentiation to effector and memory cells, or deletion. How stimulation affects cell fate is unclear. Autonomous CD8+ T cell differentiation has been proposed, but this does not explain the abortive proliferation of T cells induced by i...

journal_title：Nature immunology

authors： Gett AV,Sallusto F,Lanzavecchia A,Geginat J

更新日期：2003-04-01 00:00:00

abstract：:Stimulation of Toll-like receptors (TLRs) initiates potent innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by the TLR3 ligand double-stran...

journal_title：Nature immunology

authors： Meylan E,Burns K,Hofmann K,Blancheteau V,Martinon F,Kelliher M,Tschopp J

更新日期：2004-05-01 00:00:00

abstract：:The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transducti...

journal_title：Nature immunology

authors： Liu X,Bosselut R

更新日期：2004-03-01 00:00:00

abstract：:The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexit...

journal_title：Nature immunology

authors： Zhao H,Nguyen H,Kang J

更新日期：2005-12-01 00:00:00

abstract：:Immunological reactions are propelled by ever-changing signals that alter the translational ability of the RNA in the cells involved. Such alterations are considered to be consequential modifications in the transcriptomic decoding of the genetic blueprint. The identification of RNA-binding protein (RBP) assemblies eng...

journal_title：Nature immunology

authors： Kafasla P,Skliris A,Kontoyiannis DL

更新日期：2014-06-01 00:00:00

abstract：:CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gen...

journal_title：Nature immunology

authors： Shimizu J,Yamazaki S,Takahashi T,Ishida Y,Sakaguchi S

更新日期：2002-02-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Fehervari Z

更新日期：2018-11-01 00:00:00