Abstract:
:Immunological reactions are propelled by ever-changing signals that alter the translational ability of the RNA in the cells involved. Such alterations are considered to be consequential modifications in the transcriptomic decoding of the genetic blueprint. The identification of RNA-binding protein (RBP) assemblies engaged in the coordinative regulation of state-specific RNAs indicates alternative and exclusive means for determining the activation, plasticity and tolerance of cells of the immune system. Here we review current knowledge about RBP-regulated post-transcriptional events involved in the reactivity of cells of the immune system and the importance of their alteration during chronic inflammatory pathology and autoimmunity.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Kafasla P,Skliris A,Kontoyiannis DLdoi
10.1038/ni.2884subject
Has Abstractpub_date
2014-06-01 00:00:00pages
492-502issue
6eissn
1529-2908issn
1529-2916pii
ni.2884journal_volume
15pub_type
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