Abstract:
:The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Brown GDdoi
10.1038/ni1008-1099subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1099-100issue
10eissn
1529-2908issn
1529-2916pii
ni1008-1099journal_volume
9pub_type
评论,杂志文章,评审abstract::Regulatory T cells (T(reg) cells) develop from progenitor thymocytes after the engagement of T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular mechanisms are still unclear. Here we show that the Nr4a nuclear receptors, which are encoded by immediate-early genes upregulated by TCR...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2520
更新日期:2013-03-01 00:00:00
abstract::Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intra...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2573
更新日期:2013-06-01 00:00:00
abstract::More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1009-1039
更新日期:2009-10-01 00:00:00
abstract::Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2395
更新日期:2012-10-01 00:00:00
abstract::Using a human CD25 reporter transgene controlled by regulatory sequences from the gene encoding pre-T cell receptor alpha, we identified a common lymphocyte precursor (CLP-2) population that, in contrast to the previously identified CLP-1 population, was c-Kit-B220+. In short-term culture, the CLP-2 could be derived f...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni965
更新日期:2003-09-01 00:00:00
abstract::Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill tissue-specific and niche-specific functions. These range from dedicated homeostatic functions, such as clearance of cellular debris and iron processing, to central roles in tissue immune surveillance, response to infection and the...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2705
更新日期:2013-10-01 00:00:00
abstract::Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monoc...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0568-x
更新日期:2020-02-01 00:00:00
abstract::Although much is known about the migration of T cells from blood to lymph nodes, less is known about the mechanisms regulating the migration of T cells from tissues into lymph nodes through afferent lymphatics. Here we investigated T cell egress from nonlymphoid tissues into afferent lymph in vivo and developed an exp...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1534
更新日期:2008-01-01 00:00:00
abstract::It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and pro...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni845
更新日期:2002-11-01 00:00:00
abstract::Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells (DCs) and macrophages. Because there is no precedent for immune receptor signaling in the ER, we investigated how TLR9 is act...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1028
更新日期:2004-02-01 00:00:00
abstract::Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3324
更新日期:2016-01-01 00:00:00
abstract::Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-negative isoforms that interfere with its activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL). Here we found that conditional inactivation of the Ikaros DNA-binding domain in e...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2821
更新日期:2014-03-01 00:00:00
abstract::The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1085
更新日期:2004-07-01 00:00:00
abstract::Recent studies have highlighted the structural requirements for T cell costimulation and have revealed unusual modes of dimerization for the cytolytic T lymphocyte-associated antigen 4 (CTLA-4) costimulatory receptor and its B7 ligands. These distinctive quaternary structures potentially endow both receptor and ligand...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni0502-427
更新日期:2002-05-01 00:00:00
abstract::The duration of T cell receptor (TCR) signaling is thought to be important for thymocyte differentiation into the CD4 or CD8 lineage. However, the in vivo relevance of this hypothesis is unclear. Here we divided T cell positive selection into genetically separable developmental steps by confining TCR signal transducti...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1040
更新日期:2004-03-01 00:00:00
abstract::CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0760-z
更新日期:2020-10-01 00:00:00
abstract::During the productive interaction of T cells with antigen-presenting cells (APCs), engaged receptors, including the T cell antigen receptors and their associated tyrosine kinases, assemble into spatially segregated supramolecular activation clusters (SMACs) at the area of cell contact. Here, we studied intracellular s...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni836
更新日期:2002-10-01 00:00:00
abstract::Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test whether loss of Nedd4 affects T cells in the same way, we generated Nedd4(+/+) and Nedd4(-/-) fetal l...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1670
更新日期:2008-12-01 00:00:00
abstract::Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokin...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/90675
更新日期:2001-08-01 00:00:00
abstract::Infection of erythrocytes with Plasmodium species induces clinical malaria. Parasite-specific CD4(+) T cells correlate with lower parasite burdens and severity of human malaria and are needed to control blood-stage infection in mice. However, the characteristics of CD4(+) T cells that determine protection or parasite ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2180
更新日期:2011-12-11 00:00:00
abstract::We evaluated changes in the signaling potentials and proliferative capacity of single antigen-specific T helper (TH) cells during a primary immune response to a protein antigen. At the peak of cellular expansion in vivo all antigen-specific TH cells exhibited a profound block in CD3- and CD4-mediated mobilization of i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/80841
更新日期:2000-11-01 00:00:00
abstract::Helper T cells control host defense against pathogens. The receptors for interleukin 12 (IL-12), IL-4 and IL-6 are required for differentiation into the T(H)1, T(H)2 and T(H)17 subsets of helper T cells, respectively. IL-2 signaling via the transcription factor STAT5 controls T(H)2 differentiation by regulating both t...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2030
更新日期:2011-06-01 00:00:00
abstract::Store-operated Ca2+ entry through calcium release-activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in immune cells. Here we show that mouse T cells and fibroblasts lacking the calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sen...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1574
更新日期:2008-04-01 00:00:00
abstract::Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1226
更新日期:2005-08-01 00:00:00
abstract::Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations. The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases. ...
journal_title:Nature immunology
pub_type:
doi:10.1038/ni0910-769
更新日期:2010-09-01 00:00:00
abstract::Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-d...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1772
更新日期:2009-09-01 00:00:00
abstract::The extracellular protein Spätzle is required for activation of the Toll signaling pathway in the embryonic development and innate immune defense of Drosophila. Spätzle is synthesized as a pro-protein and is processed to a functional form by a serine protease. We show here that the mature form of Spätzle triggers a To...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni955
更新日期:2003-08-01 00:00:00
abstract::The lineage commitment of CD4+ T cells is coordinately regulated by signals through the T cell receptor and cytokine receptors, yet how these signals are integrated remains elusive. Here we find that mice lacking Dock2, a Rac activator in lymphocytes, developed allergic disease through a mechanism dependent on CD4+ T ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1506
更新日期:2007-10-01 00:00:00
abstract::Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/87766
更新日期:2001-05-01 00:00:00
abstract::Toll-like receptor 2 (TLR2) initiates inflammation in response to bacterial lipopeptide (BLP). However, the molecular mechanisms enabling the detection of BLP by TLR2 are unknown. Here we investigated the interaction of BLP with human serum proteins and identified vitronectin as a BLP-recognition molecule. Vitronectin...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1618
更新日期:2008-07-01 00:00:00