Abstract：
:Toll-like receptor 2 (TLR2) initiates inflammation in response to bacterial lipopeptide (BLP). However, the molecular mechanisms enabling the detection of BLP by TLR2 are unknown. Here we investigated the interaction of BLP with human serum proteins and identified vitronectin as a BLP-recognition molecule. Vitronectin and its receptor, integrin beta(3), were required for BLP-induced TLR2-mediated activation of human monocytes. Furthermore, monocytes from patients with Glanzmann thrombasthenia, which lack integrin beta(3), were completely unresponsive to BLP. In addition, integrin beta(3) formed a complex with TLR2 and this complex dissociated after BLP stimulation. Notably, vitronectin and integrin beta(3) coordinated responses to other TLR2 agonists such as lipoteichoic acid and zymosan. Our findings show that vitronectin and integrin beta(3) contribute to the initiation of TLR2 responses.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Gerold G,Abu Ajaj K,Bienert M,Laws HJ,Zychlinsky A,de Diego JLdoi
10.1038/ni.1618subject
Has Abstractpub_date
2008-07-01 00:00:00pages
761-8issue
7eissn
1529-2908issn
1529-2916pii
ni.1618journal_volume
9pub_type
杂志文章abstract：:Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear. Here we describe a mechanism for signal integration based on the functional coupling of two distinct signaling pathways widely used i...
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更新日期：2006-07-01 00:00:00
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