当前位置： SCI文献检索 > NATURE IMMUNOLOGY期刊下所有文献 > The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination.

The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination.

Abstract：

:Although approximately 200 viral microRNAs are known, only very few share similar targets with their host's microRNAs. A notable example of this is the stress-induced ligand MICB, which is targeted by several distinct viral and cellular microRNAs. Through the investigation of the microRNA-mediated immune-evasion strategies of herpesviruses, we initially identified two new cellular microRNAs that targeted MICB and were expressed differently both in healthy tissues and during melanocyte transformation. We show that coexpression of various pairs of cellular microRNAs interfered with the downregulation of MICB, whereas the viral microRNAs optimized their targeting ability to efficiently downregulate MICB. Moreover, we demonstrate that through site proximity and possibly inhibition of translation, a human cytomegalovirus (HCMV) microRNA acts synergistically with a cellular microRNA to suppress MICB expression during HCMV infection.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Nachmani D,Lankry D,Wolf DG,Mandelboim O

doi

10.1038/ni.1916

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

806-13

issue

9

eissn

1529-2908

issn

1529-2916

pii

ni.1916

journal_volume

11

pub_type

杂志文章

相关文献

NATURE IMMUNOLOGY文献大全
  • Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.

    abstract：:Regulated glycosylation controls T cell processes, including activation, differentiation and homing by creating or masking ligands for endogenous lectins. Here we show that stimuli promoting T helper type 1 (TH1), TH2 or interleukin 17-producing T helper (TH-17) differentiation can differentially regulate the glycosyl...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1482

    authors： Toscano MA,Bianco GA,Ilarregui JM,Croci DO,Correale J,Hernandez JD,Zwirner NW,Poirier F,Riley EM,Baum LG,Rabinovich GA

    更新日期：2007-08-01 00:00:00

  • NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance.

    abstract：:Tolerance to endotoxins that is triggered by prior exposure to Toll-like receptor (TLR) ligands provides a mechanism with which to dampen inflammatory cytokines. The receptor-interacting protein RIP140 interacts with the transcription factor NF-κB to regulate the expression of genes encoding proinflammatory cytokines....

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2238

    authors： Ho PC,Tsui YC,Feng X,Greaves DR,Wei LN

    更新日期：2012-03-04 00:00:00

  • Two isoforms of otubain 1 regulate T cell anergy via GRAIL.

    abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1017

    authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

    更新日期：2004-01-01 00:00:00

  • Plant NBS-LRR proteins in pathogen sensing and host defense.

    abstract：:Plant proteins belonging to the nucleotide-binding site-leucine-rich repeat (NBS-LRR) family are used for pathogen detection. Like the mammalian Nod-LRR protein 'sensors' that detect intracellular conserved pathogen-associated molecular patterns, plant NBS-LRR proteins detect pathogen-associated proteins, most often t...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni1410

    authors： DeYoung BJ,Innes RW

    更新日期：2006-12-01 00:00:00

  • Origins of the T(H)1-T(H)2 model: a personal perspective.

    abstract：:Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1-T helper type 2 hypothesis. ...

    journal_title：Nature immunology

    pub_type： 传,历史文章,杂志文章

    doi：10.1038/ni0606-539

    authors： Coffman RL

    更新日期：2006-06-01 00:00:00

  • Cross-regulation of signaling by ITAM-associated receptors.

    abstract：:An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family ...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.1706

    authors： Ivashkiv LB

    更新日期：2009-04-01 00:00:00

  • A tissue checkpoint regulates type 2 immunity.

    abstract：:Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3582

    authors： Van Dyken SJ,Nussbaum JC,Lee J,Molofsky AB,Liang HE,Pollack JL,Gate RE,Haliburton GE,Ye CJ,Marson A,Erle DJ,Locksley RM

    更新日期：2016-12-01 00:00:00

  • A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.

    abstract：:PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastati...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.2762

    authors： Okazaki T,Chikuma S,Iwai Y,Fagarasan S,Honjo T

    更新日期：2013-12-01 00:00:00

  • Immunometabolism of regulatory T cells.

    abstract：:The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commen...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.3466

    authors： Newton R,Priyadharshini B,Turka LA

    更新日期：2016-05-19 00:00:00

  • Critical functions for c-Myb at three checkpoints during thymocyte development.

    abstract：:The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1085

    authors： Bender TP,Kremer CS,Kraus M,Buch T,Rajewsky K

    更新日期：2004-07-01 00:00:00

  • Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells.

    abstract：:Gadd45beta (growth arrest and DNA damage-inducible, beta) is involved in cell cycle arrest, apoptosis, signal transduction and cell survival. In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals. Deficiency of Gadd45beta in CD4+ T cells impaired their responses to TCR stimulation o...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1020

    authors： Lu B,Ferrandino AF,Flavell RA

    更新日期：2004-01-01 00:00:00

  • A role for the ITAM signaling module in specifying cytokine-receptor functions.

    abstract：:Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear. Here we describe a mechanism for signal integration based on the functional coupling of two distinct signaling pathways widely used i...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2845

    authors： Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

    更新日期：2014-04-01 00:00:00

  • An innate antiviral pathway acting before interferons at epithelial surfaces.

    abstract：:Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3319

    authors： Iversen MB,Reinert LS,Thomsen MK,Bagdonaite I,Nandakumar R,Cheshenko N,Prabakaran T,Vakhrushev SY,Krzyzowska M,Kratholm SK,Ruiz-Perez F,Petersen SV,Goriely S,Bibby BM,Eriksson K,Ruland J,Thomsen AR,Herold BC,Wandall H

    更新日期：2016-02-01 00:00:00

  • Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth.

    abstract：:Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional chemokine CXCL10. By extending those initial findings to pre-clinical mod...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-019-0321-5

    authors： Hollande C,Boussier J,Ziai J,Nozawa T,Bondet V,Phung W,Lu B,Duffy D,Paradis V,Mallet V,Eberl G,Sandoval W,Schartner JM,Pol S,Barreira da Silva R,Albert ML

    更新日期：2019-03-01 00:00:00

  • Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.

    abstract：:Antibody specificity and diversity is generated in B cells during germinal center maturation through clonal expansion while they undergo class-switch recombination and somatic hypermutation. Here we demonstrate that the transcriptional repressor Bcl-6 mediates this phenotype by directly repressing ATR in centroblasts ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1478

    authors： Ranuncolo SM,Polo JM,Dierov J,Singer M,Kuo T,Greally J,Green R,Carroll M,Melnick A

    更新日期：2007-07-01 00:00:00

  • The nuclear receptor LXRα controls the functional specialization of splenic macrophages.

    abstract：:Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2622

    authors： A-Gonzalez N,Guillen JA,Gallardo G,Diaz M,de la Rosa JV,Hernandez IH,Casanova-Acebes M,Lopez F,Tabraue C,Beceiro S,Hong C,Lara PC,Andujar M,Arai S,Miyazaki T,Li S,Corbi AL,Tontonoz P,Hidalgo A,Castrillo A

    更新日期：2013-08-01 00:00:00

  • Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice.

    abstract：:Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B(-/-) mice had an increased number of peritoneal B1 cells. Splenic PIR-B(-/-) B2 cells were constitutively activated and proliferated much more than th...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni801

    authors： Ujike A,Takeda K,Nakamura A,Ebihara S,Akiyama K,Takai T

    更新日期：2002-06-01 00:00:00

  • Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.

    abstract：:Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-018-0230-z

    authors： Povoleri GAM,Nova-Lamperti E,Scottà C,Fanelli G,Chen YC,Becker PD,Boardman D,Costantini B,Romano M,Pavlidis P,McGregor R,Pantazi E,Chauss D,Sun HW,Shih HY,Cousins DJ,Cooper N,Powell N,Kemper C,Pirooznia M,Laurence

    更新日期：2018-12-01 00:00:00

  • Intrusive HIV-1-infected cells.

    abstract：:Macrophages infected with human immunodeficiency virus type 1 emit long intercellular conduits that shuttle the viral protein Nef to bystander B cells, where it impairs cellular function and immunoglobulin class switching. ...

    journal_title：Nature immunology

    pub_type： 新闻

    doi：10.1038/ni0909-933

    authors： Rudnicka D,Schwartz O

    更新日期：2009-09-01 00:00:00

  • A Toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin.

    abstract：:Toll-like receptor 2 (TLR2) initiates inflammation in response to bacterial lipopeptide (BLP). However, the molecular mechanisms enabling the detection of BLP by TLR2 are unknown. Here we investigated the interaction of BLP with human serum proteins and identified vitronectin as a BLP-recognition molecule. Vitronectin...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1618

    authors： Gerold G,Abu Ajaj K,Bienert M,Laws HJ,Zychlinsky A,de Diego JL

    更新日期：2008-07-01 00:00:00

  • IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.

    abstract：:Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population resp...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3078

    authors： Huang Y,Guo L,Qiu J,Chen X,Hu-Li J,Siebenlist U,Williamson PR,Urban JF Jr,Paul WE

    更新日期：2015-02-01 00:00:00

  • Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.

    abstract：:Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intra...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2573

    authors： Huang LR,Wohlleber D,Reisinger F,Jenne CN,Cheng RL,Abdullah Z,Schildberg FA,Odenthal M,Dienes HP,van Rooijen N,Schmitt E,Garbi N,Croft M,Kurts C,Kubes P,Protzer U,Heikenwalder M,Knolle PA

    更新日期：2013-06-01 00:00:00

  • Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors.

    abstract：:The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34+ progenitor cells, we found ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3789

    authors： Lee J,Zhou YJ,Ma W,Zhang W,Aljoufi A,Luh T,Lucero K,Liang D,Thomsen M,Bhagat G,Shen Y,Liu K

    更新日期：2017-08-01 00:00:00

  • The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.

    abstract：:In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2981

    authors： Lanna A,Henson SM,Escors D,Akbar AN

    更新日期：2014-10-01 00:00:00

  • Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

    abstract：:Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of α-smooth muscle actin (α-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2408

    authors： Ludin A,Itkin T,Gur-Cohen S,Mildner A,Shezen E,Golan K,Kollet O,Kalinkovich A,Porat Z,D'Uva G,Schajnovitz A,Voronov E,Brenner DA,Apte RN,Jung S,Lapidot T

    更新日期：2012-11-01 00:00:00

  • Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells.

    abstract：:Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an in...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.2018

    authors： Sprent J,Surh CD

    更新日期：2011-06-01 00:00:00

  • Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria.

    abstract：:Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1869

    authors： Belyaev NN,Brown DE,Diaz AI,Rae A,Jarra W,Thompson J,Langhorne J,Potocnik AJ

    更新日期：2010-06-01 00:00:00

  • Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes.

    abstract：:In the version of this article initially published, some identification of the supplementary information was incorrect. The items originally called Supplementary Tables 1, 2, 3, 4 and 5 should be Source Data Figures 1, 2, 4, 5 and 7, respectively; those originally called Supplementary Tables 6, 7 and 8 should be Suppl...

    journal_title：Nature immunology

    pub_type： 已发布勘误

    doi：10.1038/s41590-018-0154-7

    authors： Zhang M,Dong Y,Hu F,Yang D,Zhao Q,Lv C,Wang Y,Xia C,Weng Q,Liu X,Li C,Zhou P,Wang T,Guan Y,Guo R,Liu L,Geng Y,Wu H,Du J,Hu Z,Xu S,Chen J,He A,Liu B,Wang D,Yang YG,Wang J

    更新日期：2018-09-01 00:00:00

  • Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells.

    abstract：:While a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed en...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2806

    authors： Saini AS,Shenoy GN,Rath S,Bal V,George A

    更新日期：2014-03-01 00:00:00

  • Patterns of nonclassical MHC antigen presentation.

    abstract：:The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immun...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1475

    authors： Hansen TH,Huang S,Arnold PL,Fremont DH

    更新日期：2007-06-01 00:00:00