Abstract:
:The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commensal-microbiota-derived metabolites modulate immunological homeostasis. Studies demonstrating the metabolic similarities of proliferating immune cells and cancer cells have helped give birth to the new field of immunometabolism, which focuses on how the cell-intrinsic metabolic properties of lymphocytes and macrophages can themselves dictate the fate and function of the cells and eventually shape an immune response. We focus on this aspect here, particularly as it relates to regulatory T cells.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Newton R,Priyadharshini B,Turka LAdoi
10.1038/ni.3466subject
Has Abstractpub_date
2016-05-19 00:00:00pages
618-25issue
6eissn
1529-2908issn
1529-2916pii
ni.3466journal_volume
17pub_type
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pub_type: 杂志文章
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abstract::Immune synapses form between T cells and antigen-presenting cells (APCs). Increasing evidence suggests synapses must form flexibly to accommodate ongoing motility and displacement of the synapse. Here, time-lapse total internal reflection fluorescence (TIRF) microscopy showed that signaling via the T cell antigen rece...
journal_title:Nature immunology
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-019-0531-x
更新日期:2019-11-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 评论,杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1379
更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-05-22 00:00:00
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更新日期:2001-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni965
更新日期:2003-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni908
更新日期:2003-04-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1303
更新日期:2006-02-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni959
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pub_type: 杂志文章
doi:10.1038/ni1025
更新日期:2004-02-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni976
更新日期:2003-10-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni836
更新日期:2002-10-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1063
更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-11-20 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni955
更新日期:2003-08-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2491
更新日期:2013-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2570
更新日期:2013-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,已发布勘误
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更新日期:2020-06-01 00:00:00
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