T cell fitness determined by signal strength.

abstract：:Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal transducer and activator of transcription') family constitute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune system. Research on this paradigmatic pathway has experienced brea...

journal_title：Nature immunology

authors： Villarino AV,Kanno Y,O'Shea JJ

更新日期：2017-03-22 00:00:00

abstract：:The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process. ...

journal_title：Nature immunology

authors： Brown GD

更新日期：2008-10-01 00:00:00

abstract：:The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential role in supporting ...

journal_title：Nature immunology

authors： Everts B,Amiel E,Huang SC,Smith AM,Chang CH,Lam WY,Redmann V,Freitas TC,Blagih J,van der Windt GJ,Artyomov MN,Jones RG,Pearce EL,Pearce EJ

更新日期：2014-04-01 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution co...

journal_title：Nature immunology

authors： Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB,ImmGen Project Consortium.

更新日期：2013-01-01 00:00:00

abstract：:Mutational spectra analysis of 15 immunoglobulin genes suggested that consensus motifs RGYW and WA were universal descriptors of somatic hypermutation. Highly mutable sites, "hotspots", that matched WA were preferentially found in one DNA strand and RGYW hotspots were found in both strands. Analysis of base-substituti...

journal_title：Nature immunology

authors： Rogozin IB,Pavlov YI,Bebenek K,Matsuda T,Kunkel TA

更新日期：2001-06-01 00:00:00

abstract：:Foxp3+ regulatory T cells (Treg cells) are the central component of peripheral immune tolerance. Whereas a dysregulated Treg cytokine signature has been observed in autoimmune diseases, the regulatory mechanisms underlying pro- and anti-inflammatory cytokine production are elusive. Here, we identify an imbalance betwe...

journal_title：Nature immunology

authors： Sumida T,Lincoln MR,Ukeje CM,Rodriguez DM,Akazawa H,Noda T,Naito AT,Komuro I,Dominguez-Villar M,Hafler DA

更新日期：2018-12-01 00:00:00

abstract：:The kappa intronic (MiE(kappa)) and 3' (3'E(kappa)) enhancers are both quantitatively important to, but not essential for, immunoglobulin kappa rearrangement. To determine the functional redundancy between these two enhancers, B cells derived from mutant embryonic stem cells--in which both MiE(kappa) and 3'E(kappa) we...

journal_title：Nature immunology

authors： Inlay M,Alt FW,Baltimore D,Xu Y

更新日期：2002-05-01 00:00:00

abstract：:Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized to produce peptides presented on class I major histocompatibility complex molecules. We found that purified ERAP1 trimmed peptides that were ten residues or longer, but spared eight-residue peptides. In vivo, ERAP1 enhanced production of an ...

journal_title：Nature immunology

authors： York IA,Chang SC,Saric T,Keys JA,Favreau JM,Goldberg AL,Rock KL

更新日期：2002-12-01 00:00:00

abstract：:During the productive interaction of T cells with antigen-presenting cells (APCs), engaged receptors, including the T cell antigen receptors and their associated tyrosine kinases, assemble into spatially segregated supramolecular activation clusters (SMACs) at the area of cell contact. Here, we studied intracellular s...

journal_title：Nature immunology

authors： Freiberg BA,Kupfer H,Maslanik W,Delli J,Kappler J,Zaller DM,Kupfer A

更新日期：2002-10-01 00:00:00

abstract：:Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-6...

journal_title：Nature immunology

authors： Köhler F,Storch B,Kulathu Y,Herzog S,Kuppig S,Reth M,Jumaa H

更新日期：2005-02-01 00:00:00

abstract：:Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of...

journal_title：Nature immunology

authors： Zhou H,Wang H,Yu M,Schugar RC,Qian W,Tang F,Liu W,Yang H,McDowell RE,Zhao J,Gao J,Dongre A,Carman JA,Yin M,Drazba JA,Dent R,Hine C,Chen YR,Smith JD,Fox PL,Brown JM,Li X

更新日期：2020-10-01 00:00:00

abstract：:The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sp...

journal_title：Nature immunology

authors： Koch M,Stronge VS,Shepherd D,Gadola SD,Mathew B,Ritter G,Fersht AR,Besra GS,Schmidt RR,Jones EY,Cerundolo V

更新日期：2005-08-01 00:00:00

abstract：:CD4(+) T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (T(H)1) or T(H)2 lineages and instead favor the idea of a d...

journal_title：Nature immunology

authors： Harrington LE,Hatton RD,Mangan PR,Turner H,Murphy TL,Murphy KM,Weaver CT

更新日期：2005-11-01 00:00:00

abstract：:Induction of the transcriptional repressor Bcl-6 in CD4(+) T cells is critical for the differentiation of follicular helper T cells (T(FH) cells), which are essential for B cell-mediated immunity. In contrast, the transcription factor Blimp1 (encoded by Prdm1) inhibits T(FH) differentiation by antagonizing Bcl-6. Here...

journal_title：Nature immunology

authors： Xu L,Cao Y,Xie Z,Huang Q,Bai Q,Yang X,He R,Hao Y,Wang H,Zhao T,Fan Z,Qin A,Ye J,Zhou X,Ye L,Wu Y

更新日期：2015-09-01 00:00:00

abstract：:We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes, and mTORC1 selectively repressed and promoted expression of a subset of CTL proteins (~10%)....

journal_title：Nature immunology

authors： Hukelmann JL,Anderson KE,Sinclair LV,Grzes KM,Murillo AB,Hawkins PT,Stephens LR,Lamond AI,Cantrell DA

更新日期：2016-01-01 00:00:00

abstract：:Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to i...

journal_title：Nature immunology

authors： Aaby P,Kollmann TR,Benn CS

更新日期：2014-10-01 00:00:00

abstract：:The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the inte...

journal_title：Nature immunology

authors： Vacchio MS,Wang L,Bouladoux N,Carpenter AC,Xiong Y,Williams LC,Wohlfert E,Song KD,Belkaid Y,Love PE,Bosselut R

更新日期：2014-10-01 00:00:00

abstract：:The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi...

journal_title：Nature immunology

authors： Leulier F,Parquet C,Pili-Floury S,Ryu JH,Caroff M,Lee WJ,Mengin-Lecreulx D,Lemaitre B

更新日期：2003-05-01 00:00:00

abstract：:Double-stranded DNA (dsDNA) in the cytoplasm triggers the production of interleukin 1β (IL-1β) as an antiviral host response, and deregulation of the pathways involved can promote inflammatory disease. Here we report a direct cytosolic interaction between the DNA-damage sensor Rad50 and the innate immune system adapto...

journal_title：Nature immunology

authors： Roth S,Rottach A,Lotz-Havla AS,Laux V,Muschaweckh A,Gersting SW,Muntau AC,Hopfner KP,Jin L,Vanness K,Petrini JH,Drexler I,Leonhardt H,Ruland J

更新日期：2014-06-01 00:00:00

abstract：:Indoleamine 2,3 dioxygenase (IDO) activity during pregnancy protects developing fetuses from maternal immune responses in CBA mice. We show here that fetal allografts were rejected only in mating combinations where paternally inherited tissue antigens elicited potent maternal T cell responses after exposure to IDO inh...

journal_title：Nature immunology

authors： Mellor AL,Sivakumar J,Chandler P,Smith K,Molina H,Mao D,Munn DH

更新日期：2001-01-01 00:00:00

abstract：:Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentrations. Here we show that the conditional deletion o...

journal_title：Nature immunology

authors： Anzelon AN,Wu H,Rickert RC

更新日期：2003-03-01 00:00:00

abstract：:CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral inter...

journal_title：Nature immunology

authors： Yewdell JW,Hill AB

更新日期：2002-11-01 00:00:00

abstract：:The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibility was identified early in the pandemic, with a major role attr...

journal_title：Nature immunology

authors： McLaren PJ,Carrington M

更新日期：2015-06-01 00:00:00

abstract：:Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to i...

journal_title：Nature immunology

authors： Fan QR,Long EO,Wiley DC

更新日期：2001-05-01 00:00:00

abstract：:Interferon-γ (IFN-γ) is essential for the innate immune response to intracellular bacteria. Noncoding RNAs and RNA-binding proteins (RBPs) need to be further considered in studies of regulation of the IFN-γ-activated signaling pathway in macrophages. In the present study, we found that the microRNA miR-1 promoted IFN-...

journal_title：Nature immunology

authors： Xu H,Jiang Y,Xu X,Su X,Liu Y,Ma Y,Zhao Y,Shen Z,Huang B,Cao X

更新日期：2019-12-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) develop from progenitor thymocytes after the engagement of T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular mechanisms are still unclear. Here we show that the Nr4a nuclear receptors, which are encoded by immediate-early genes upregulated by TCR...

journal_title：Nature immunology

authors： Sekiya T,Kashiwagi I,Yoshida R,Fukaya T,Morita R,Kimura A,Ichinose H,Metzger D,Chambon P,Yoshimura A

更新日期：2013-03-01 00:00:00

abstract：:Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and...

journal_title：Nature immunology

authors： Ahmed N,Zeng M,Sinha I,Polin L,Wei WZ,Rathinam C,Flavell R,Massoumi R,Venuprasad K

更新日期：2011-11-06 00:00:00

abstract：:High-throughput 3' single-cell RNA-sequencing (scRNA-seq) allows cost-effective, detailed characterization of individual immune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including variable sequences of T cell antigen receptors (TCRs) that...

journal_title：Nature immunology

authors： Tu AA,Gierahn TM,Monian B,Morgan DM,Mehta NK,Ruiter B,Shreffler WG,Shalek AK,Love JC

更新日期：2019-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Roquilly A,Jacqueline C,Davieau M,Mollé A,Sadek A,Fourgeux C,Rooze P,Broquet A,Misme-Aucouturier B,Chaumette T,Vourc'h M,Cinotti R,Marec N,Gauttier V,McWilliam HEG,Altare F,Poschmann J,Villadangos JA,Asehnoune K

更新日期：2020-08-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2019-01-01 00:00:00