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Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.

Abstract：

:The kappa intronic (MiE(kappa)) and 3' (3'E(kappa)) enhancers are both quantitatively important to, but not essential for, immunoglobulin kappa rearrangement. To determine the functional redundancy between these two enhancers, B cells derived from mutant embryonic stem cells--in which both MiE(kappa) and 3'E(kappa) were deleted on both kappa alleles--were analyzed for kappa rearrangement. Our findings indicate that these double-mutant B cells have essentially no kappa rearrangement but do rearrange and express lambda. Therefore, these two kappa enhancers share essential roles in activating V(kappa)J(kappa) rearrangement. Our findings also indicate that the two kappa enhancers play overlapping and distinct roles in the demethylation of kappa in B cells.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Inlay M,Alt FW,Baltimore D,Xu Y

doi

10.1038/ni790

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

463-8

issue

5

eissn

1529-2908

issn

1529-2916

pii

ni790

journal_volume

3

pub_type

杂志文章

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