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Egr-2 and Egr-3 are negative regulators of T cell activation.

Abstract：

:T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth response gene 2 (Egr-2) and Egr-3 as key negative regulators of T cell activation. Overexpression of Egr2 and Egr3 was associated with an increase in the E3 ubiquitin ligase Cbl-b and inhibition of T cell activation. Conversely, T cells from Egr3(-/-) mice had lower expression of Cbl-b and were resistant to in vivo peptide-induced tolerance. These data support the idea that Egr-2 and Egr-3 are involved in promoting a T cell receptor-induced negative regulatory genetic program.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Safford M,Collins S,Lutz MA,Allen A,Huang CT,Kowalski J,Blackford A,Horton MR,Drake C,Schwartz RH,Powell JD

doi

10.1038/ni1193

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

472-80

issue

5

eissn

1529-2908

issn

1529-2916

pii

ni1193

journal_volume

6

pub_type

杂志文章

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