Abstract:
:Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of the expression of costimulatory molecules and chemokine production. Furthermore, TH2 responses in mice with DC-specific loss of STAT5 resembled those seen in mice deficient in the receptor for TSLP. Our results show that the TSLP-STAT5 axis in DCs is a critical component for the promotion of type 2 immunity at barrier surfaces.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SFdoi
10.1038/ni.2541subject
Has Abstractpub_date
2013-04-01 00:00:00pages
364-71issue
4eissn
1529-2908issn
1529-2916pii
ni.2541journal_volume
14pub_type
杂志文章abstract:: ...
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journal_title:Nature immunology
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni910
更新日期:2003-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1607
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1475
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0156-5
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journal_title:Nature immunology
pub_type: 评论,新闻
doi:10.1038/ni.2115
更新日期:2011-09-20 00:00:00
abstract::The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR ne...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1860
更新日期:2010-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni742
更新日期:2002-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3096
更新日期:2015-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0321-5
更新日期:2019-03-01 00:00:00
abstract::Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate t...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0176-1
更新日期:2018-09-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/80841
更新日期:2000-11-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
abstract::Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of...
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pub_type: 杂志文章
doi:10.1038/s41590-020-0750-1
更新日期:2020-10-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1085
更新日期:2004-07-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1196
更新日期:2005-05-01 00:00:00
abstract::Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2622
更新日期:2013-08-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2018
更新日期:2011-06-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2033
更新日期:2011-05-22 00:00:00
abstract::High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA sensing in tumor cells after radiation is rather limited. Here we demonstrate that irradiated tumor cells hijack caspase 9 signaling to suppress intrinsic DNA sensi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0641-5
更新日期:2020-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2230
更新日期:2012-02-05 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0582-z
更新日期:2020-02-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 评论,杂志文章
doi:10.1038/s41590-018-0240-x
更新日期:2018-11-01 00:00:00
abstract::The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1789
更新日期:2009-11-01 00:00:00
abstract::Gadd45beta (growth arrest and DNA damage-inducible, beta) is involved in cell cycle arrest, apoptosis, signal transduction and cell survival. In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals. Deficiency of Gadd45beta in CD4+ T cells impaired their responses to TCR stimulation o...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1020
更新日期:2004-01-01 00:00:00
abstract::Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2051
更新日期:2011-06-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
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更新日期:2020-01-01 00:00:00
abstract::In neutrophils, superoxide anion production generally accompanies chemotaxis and functions in killing invading pathogens. The GIT2 GTPase-activating protein binds to the guanine nucleotide-exchange factor alphaPIX. Here we show that GIT2 was necessary for directional chemotaxis and for the suppression of superoxide pr...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1349
更新日期:2006-07-01 00:00:00