T cells down-modulate peptide-MHC complexes on APCs in vivo.

Abstract:

:T cells compete in the response to antigen in vivo and this competition may drive the affinity maturation of a secondary T cell response. Here we show that high-affinity T cells out-competed lower affinity T cells during a response to antigenic challenge in vivo. Although competition between T cells specific for different peptide-major histocompatibility complexes (MHC) occurred, it was less efficient than competition between T cells of the same peptide-MHC specificity. In addition, high-affinity T cells efficiently induced antigen loss from the surface of antigen-presenting cells. Thus T cells that responded to the same peptide-MHC competed with each other by lowering the amount of ligand with which the cells could react. As a result, the activation of high-affinity cells was favored. This provides a mechanism for the affinity maturation of a secondary T cell response.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Kedl RM,Schaefer BC,Kappler JW,Marrack P

doi

10.1038/ni742

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

27-32

issue

1

eissn

1529-2908

issn

1529-2916

pii

ni742

journal_volume

3

pub_type

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