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Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.

Abstract：

:In neutrophils, superoxide anion production generally accompanies chemotaxis and functions in killing invading pathogens. The GIT2 GTPase-activating protein binds to the guanine nucleotide-exchange factor alphaPIX. Here we show that GIT2 was necessary for directional chemotaxis and for the suppression of superoxide production in G protein-coupled receptor-stimulated neutrophils. GIT2 was also necessary for the orientation of superoxide production toward chemoattractant sources. GIT2 suppressed the activity of ADP ribosylation factor 1 and was a component of the Gbetagamma subunit-mediated direction-sensing machinery 'downstream' of G protein-coupled receptor signaling. This study establishes a function for GIT2 in linking chemotaxis and superoxide production in neutrophils and shows that loss of GIT2 in vivo leads to an immunodeficient state.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Mazaki Y,Hashimoto S,Tsujimura T,Morishige M,Hashimoto A,Aritake K,Yamada A,Nam JM,Kiyonari H,Nakao K,Sabe H

doi

10.1038/ni1349

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

724-31

issue

7

eissn

1529-2908

issn

1529-2916

pii

ni1349

journal_volume

7

pub_type

杂志文章

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