当前位置： SCI文献检索 > NATURE IMMUNOLOGY期刊下所有文献 > TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells.

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells.

Abstract：

:TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation of invariant natural killer T cells (iNKT cells). Tet2-Tet3 double-knockout (DKO) iNKT cells displayed pronounced skewing toward the NKT17 lineage, with increased DNA methylation and impaired expression of genes encoding the key lineage-specifying factors T-bet and ThPOK. Transfer of purified Tet2-Tet3 DKO iNKT cells into immunocompetent recipient mice resulted in an uncontrolled expansion that was dependent on the nonclassical major histocompatibility complex (MHC) protein CD1d, which presents lipid antigens to iNKT cells. Our data indicate that TET proteins regulate iNKT cell fate by ensuring their proper development and maturation and by suppressing aberrant proliferation mediated by the T cell antigen receptor (TCR).

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Tsagaratou A,González-Avalos E,Rautio S,Scott-Browne JP,Togher S,Pastor WA,Rothenberg EV,Chavez L,Lähdesmäki H,Rao A

doi

10.1038/ni.3630

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

45-53

issue

1

eissn

1529-2908

issn

1529-2916

pii

ni.3630

journal_volume

18

pub_type

杂志文章

相关文献

NATURE IMMUNOLOGY文献大全
  • The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.

    abstract：:Tim-3 is a T helper type 1 (T(H)1)-specific cell surface molecule that seems to regulate T(H)1 responses and the induction of peripheral tolerance. However, the identity of the Tim-3 ligand and the mechanism by which this ligand inhibits the function of effector T(H)1 cells remain unknown. Here we show that galectin-9...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1271

    authors： Zhu C,Anderson AC,Schubart A,Xiong H,Imitola J,Khoury SJ,Zheng XX,Strom TB,Kuchroo VK

    更新日期：2005-12-01 00:00:00

  • Plasma cells: finding new light at the end of B cell development.

    abstract：:Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni1201-1103

    authors： Calame KL

    更新日期：2001-12-01 00:00:00

  • The transcription factor BCL-6 controls early development of innate-like T cells.

    abstract：:Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription fact...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-020-0737-y

    authors： Gioulbasani M,Galaras A,Grammenoudi S,Moulos P,Dent AL,Sigvardsson M,Hatzis P,Kee BL,Verykokakis M

    更新日期：2020-09-01 00:00:00

  • Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.

    abstract：:Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4 (IL-4) early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we have defined three subsets of i...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2731

    authors： Lee YJ,Holzapfel KL,Zhu J,Jameson SC,Hogquist KA

    更新日期：2013-11-01 00:00:00

  • Regulation of lymphocyte development by Notch signaling.

    abstract：:Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiatio...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni1453

    authors： Tanigaki K,Honjo T

    更新日期：2007-05-01 00:00:00

  • Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.

    abstract：:The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hypervariable recepto...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-018-0305-x

    authors： Kanekiyo M,Joyce MG,Gillespie RA,Gallagher JR,Andrews SF,Yassine HM,Wheatley AK,Fisher BE,Ambrozak DR,Creanga A,Leung K,Yang ES,Boyoglu-Barnum S,Georgiev IS,Tsybovsky Y,Prabhakaran MS,Andersen H,Kong WP,Baxa U,Zephi

    更新日期：2019-03-01 00:00:00

  • Shaping a helper T cell identity.

    abstract：:Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators. ...

    journal_title：Nature immunology

    pub_type： 评论,新闻

    doi：10.1038/ni0207-119

    authors： Singh H

    更新日期：2007-02-01 00:00:00

  • A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties.

    abstract：:Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2051

    authors： Uldrich AP,Patel O,Cameron G,Pellicci DG,Day EB,Sullivan LC,Kyparissoudis K,Kjer-Nielsen L,Vivian JP,Cao B,Brooks AG,Williams SJ,Illarionov P,Besra GS,Turner SJ,Porcelli SA,McCluskey J,Smyth MJ,Rossjohn J,Godfrey DI

    更新日期：2011-06-12 00:00:00

  • The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors.

    abstract：:The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as an intrinsic negative regulator of Toll-like receptor (TLR)-triggered inflammatory responses. SHP-deficient mice were more susceptible to endotoxi...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2064

    authors： Yuk JM,Shin DM,Lee HM,Kim JJ,Kim SW,Jin HS,Yang CS,Park KA,Chanda D,Kim DK,Huang SM,Lee SK,Lee CH,Kim JM,Song CH,Lee SY,Hur GM,Moore DD,Choi HS,Jo EK

    更新日期：2011-07-03 00:00:00

  • Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

    abstract：:T cell exhaustion has a major role in failure to control chronic infection. High expression of inhibitory receptors, including PD-1, and the inability to sustain functional T cell responses contribute to exhaustion. However, the transcriptional control of these processes remains unclear. Here we demonstrate that the t...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2046

    authors： Kao C,Oestreich KJ,Paley MA,Crawford A,Angelosanto JM,Ali MA,Intlekofer AM,Boss JM,Reiner SL,Weinmann AS,Wherry EJ

    更新日期：2011-05-29 00:00:00

  • Author Correction: c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature immunology

    pub_type： 已发布勘误

    doi：10.1038/s41590-019-0554-3

    authors： Bernink JH,Ohne Y,Teunissen MBM,Wang J,Wu J,Krabbendam L,Guntermann C,Volckmann R,Koster J,van Tol S,Ramirez I,Shrestha Y,de Rie MA,Spits H,Ros XR,Humbles AA

    更新日期：2020-01-01 00:00:00

  • Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.

    abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-re...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-019-0430-1

    authors： Weizman OE,Song E,Adams NM,Hildreth AD,Riggan L,Krishna C,Aguilar OA,Leslie CS,Carlyle JR,Sun JC,O'Sullivan TE

    更新日期：2019-08-01 00:00:00

  • IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.

    abstract：:Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-020-0750-1

    authors： Zhou H,Wang H,Yu M,Schugar RC,Qian W,Tang F,Liu W,Yang H,McDowell RE,Zhao J,Gao J,Dongre A,Carman JA,Yin M,Drazba JA,Dent R,Hine C,Chen YR,Smith JD,Fox PL,Brown JM,Li X

    更新日期：2020-10-01 00:00:00

  • Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5.

    abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1226

    authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

    更新日期：2005-08-01 00:00:00

  • A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

    abstract：:Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR)...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2033

    authors： Quann EJ,Liu X,Altan-Bonnet G,Huse M

    更新日期：2011-05-22 00:00:00

  • Staging and resetting T cell activation in SMACs.

    abstract：:During the productive interaction of T cells with antigen-presenting cells (APCs), engaged receptors, including the T cell antigen receptors and their associated tyrosine kinases, assemble into spatially segregated supramolecular activation clusters (SMACs) at the area of cell contact. Here, we studied intracellular s...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni836

    authors： Freiberg BA,Kupfer H,Maslanik W,Delli J,Kappler J,Zaller DM,Kupfer A

    更新日期：2002-10-01 00:00:00

  • Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.

    abstract：:T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1321

    authors： Kallies A,Hawkins ED,Belz GT,Metcalf D,Hommel M,Corcoran LM,Hodgkin PD,Nutt SL

    更新日期：2006-05-01 00:00:00

  • Apoptosis in response to microbial infection induces autoreactive TH17 cells.

    abstract：:Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditions that allow the stimulatory presentation of self peptides themselves and that this might suffice to elicit autoreactive T ce...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3512

    authors： Campisi L,Barbet G,Ding Y,Esplugues E,Flavell RA,Blander JM

    更新日期：2016-09-01 00:00:00

  • A BATF-ling connection between B cells and follicular helper T cells.

    abstract：:The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. ...

    journal_title：Nature immunology

    pub_type： 评论,新闻

    doi：10.1038/ni.2042

    authors： Ellyard JI,Vinuesa CG

    更新日期：2011-06-01 00:00:00

  • Toll-like receptors in the pathogenesis of human disease.

    abstract：:Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These st...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni1116

    authors： Cook DN,Pisetsky DS,Schwartz DA

    更新日期：2004-10-01 00:00:00

  • Structural mechanisms of costimulation.

    abstract：:Recent studies have highlighted the structural requirements for T cell costimulation and have revealed unusual modes of dimerization for the cytolytic T lymphocyte-associated antigen 4 (CTLA-4) costimulatory receptor and its B7 ligands. These distinctive quaternary structures potentially endow both receptor and ligand...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni0502-427

    authors： Schwartz JC,Zhang X,Nathenson SG,Almo SC

    更新日期：2002-05-01 00:00:00

  • Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells.

    abstract：:Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an in...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.2018

    authors： Sprent J,Surh CD

    更新日期：2011-06-01 00:00:00

  • CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.

    abstract：:The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/76957

    authors： Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher A

    更新日期：2000-07-01 00:00:00

  • Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells.

    abstract：:Gadd45beta (growth arrest and DNA damage-inducible, beta) is involved in cell cycle arrest, apoptosis, signal transduction and cell survival. In T cells, Gadd45b was rapidly induced by T cell receptor (TCR) and inflammatory signals. Deficiency of Gadd45beta in CD4+ T cells impaired their responses to TCR stimulation o...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1020

    authors： Lu B,Ferrandino AF,Flavell RA

    更新日期：2004-01-01 00:00:00

  • Egr-2 and Egr-3 are negative regulators of T cell activation.

    abstract：:T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth respo...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1193

    authors： Safford M,Collins S,Lutz MA,Allen A,Huang CT,Kowalski J,Blackford A,Horton MR,Drake C,Schwartz RH,Powell JD

    更新日期：2005-05-01 00:00:00

  • Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.

    abstract：:Regulated glycosylation controls T cell processes, including activation, differentiation and homing by creating or masking ligands for endogenous lectins. Here we show that stimuli promoting T helper type 1 (TH1), TH2 or interleukin 17-producing T helper (TH-17) differentiation can differentially regulate the glycosyl...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1482

    authors： Toscano MA,Bianco GA,Ilarregui JM,Croci DO,Correale J,Hernandez JD,Zwirner NW,Poirier F,Riley EM,Baum LG,Rabinovich GA

    更新日期：2007-08-01 00:00:00

  • The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

    abstract：:Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2157

    authors： Ahmed N,Zeng M,Sinha I,Polin L,Wei WZ,Rathinam C,Flavell R,Massoumi R,Venuprasad K

    更新日期：2011-11-06 00:00:00

  • IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.

    abstract：:We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni875

    authors： Kotenko SV,Gallagher G,Baurin VV,Lewis-Antes A,Shen M,Shah NK,Langer JA,Sheikh F,Dickensheets H,Donnelly RP

    更新日期：2003-01-01 00:00:00

  • Publisher Correction: Macrophages: damage control.

    abstract：:In the version of this Research Highlight initially published, the url for the linked article was incorrect ( https://doi.org/10.1172/JCI90647JCI90647 ). The correct link is https://doi.org/10.1172/JCI90647 . The error has been corrected in the HTML and PDF versions of the article. ...

    journal_title：Nature immunology

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41590-018-0159-2

    authors： Fehervari Z

    更新日期：2018-08-01 00:00:00

  • Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.

    abstract：:The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived fro...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3132

    authors： Miller MS,Rialdi A,Ho JS,Tilove M,Martinez-Gil L,Moshkina NP,Peralta Z,Noel J,Melegari C,Maestre AM,Mitsopoulos P,Madrenas J,Heinz S,Benner C,Young JA,Feagins AR,Basler CF,Fernandez-Sesma A,Becherel OJ,Lavin MF,va

    更新日期：2015-05-01 00:00:00